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Understanding the function–structure and function–mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis
This high-resolution mutation analysis allows evaluation of previous predictions and hypotheses through interrelation of function, structure and mutation in the tumor suppressor p53. Expand
miRNA-223 Promotes Gastric Cancer Invasion and Metastasis by Targeting Tumor Suppressor EPB41L3
Findings indicate a new regulatory mode, namely, specific miRNA, which is activated by its upstream transcription factor, could suppress its direct targets and lead to tumor invasion and metastasis. Expand
Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.
The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region and it is demonstrated that Wwox expression triggers redistribution of nuclear p73 to the cytoplasm and, hence, suppresses its transcriptional activity. Expand
Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer
Differential patterns of WWOX and FHIT methylation were observed in neoplastic vs adjacent non-neoplastic tissues, suggesting that targeted MSP amplification could be useful in following treatment or prevention protocols. Expand
The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma
FHIT and WWOX are a tumor suppressor and a candidate suppressor that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3–24.1, respectively. Reduced or absent FhitExpand
WWOX gene restoration prevents lung cancer growth in vitro and in vivo
It is confirmed that WWOX is a tumor suppressor gene and is highly effective in preventing growth of lung cancer xenografts, whether introduced through viral infection or by induction of a silent WWOX transgene. Expand
Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library*
Results indicated that the intramolecular β-sheet in the core DNA-binding domain of p53 was a key structural element controlling the protein function and provided a clue for finding a molecular mechanism that enables the rescue of the mutant p53 function. Expand
Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition.
It is suggested that HIF-1alpha induces Twist expression in hypoxic tubular cells and that this plays a role in EMT during renal fibrogenesis. Expand
Fish consumption and colorectal cancer risk in humans: a systematic review and meta-analysis.
The findings from this meta-analysis suggest that fish consumption is inversely associated with colorectal cancer. Expand
c-Jun NH2-Terminal Kinase 2α2 Promotes the Tumorigenicity of Human Glioblastoma Cells
Evidence is provided that JNK2α2 is the major active JNK isoform and is involved in the promotion of proliferation and growth of human glioblastoma tumors through specific activation of AKT and overexpression of eIF4E. Expand