Learn More
In human neutrophils, TNF-elicited O(2)(-) production requires adherence and integrin activation. How this cooperative signaling between TNFRs and integrins regulates O(2)(-) generation has yet to be fully elucidated. Previously, we identified delta-PKC as a critical early regulator of TNF signaling in adherent neutrophils. In this study, we demonstrate(More)
One of the challenging issues in the domain of C2 in complex and urban terrain is how to assist human combat staff to effectively collaborate and make decisions under multiple contexts, and to help people switch their attentions to the most urgent decision tasks. This paper describes a comprehensive approach that uses RPD-enabled agents to support timely(More)
TNF is implicated in the suppression of neutrophil apoptosis during sepsis. Multiple signaling pathways are involved in TNF-mediated antiapoptotic signaling; a role for the MAP kinases (MAPK), ERK1/2, and p38 MAPK has been suggested. Antiapoptotic signaling is mediated principally through TNF receptor-1 (TNFR-1), and the PKC isotype-delta (delta-PKC) is a(More)
Excessive neutrophil migration across the pulmonary endothelium into the lung and release of oxidants and proteases are key elements in pathogenesis of acute lung injury. Previously, we identified protein kinase C-delta (PKCδ) as an important regulator of proinflammatory signaling in human neutrophils and demonstrated that intratracheal instillation of a(More)
Proactive information sharing is a challenging issue faced by intelligence agencies in effectively making critical decisions under time pressure in areas related to homeland security. Motivated by psychological studies on human teams, a team-oriented agent architecture, Collaborative Agents for Simulating Teamwork (CAST), was implemented to allow agents in(More)
This paper describes the concept of workflow merge and methods for merging business processes. We grouped merges in four categories according to the type of merge: sequential, parallel, conditional, and iterative, and describe the corresponding algorithms for performing these operations. We give results that allow us to determine whether a merge operation(More)
Guillain-Barré syndrome (GBS), the axonal subtype of which is mainly triggered by C. jejuni with ganglioside-mimicking lipooligosaccharides (LOS), is an immune-mediated disorder in the peripheral nervous system (PNS) accompanied by the disruption of the blood-nerve barrier (BNB) and the blood-cerebrospinal fluid barrier (B-CSF-B). Biomarkers of GBS have(More)
TNF is implicated in the attenuation of neutrophil constitutive apoptosis during sepsis. Antiapoptotic signaling is mediated principally through the TNF receptor-1 (TNFR-1). In adherent neutrophils, when beta-integrin signaling is activated, TNF phosphorylates TNFR-1 and activates prosurvival and antiapoptotic signaling. Previously, we identified the(More)
There has been much research investigating team cognition, naturalistic decision making, and collaborative technology as it relates to real world, complex domains of practice. However, there has been limited work in incorporating naturalistic decision making models for supporting distributed team decision making. The aim of this research is to support human(More)
Team decision making under stress involving multiple contexts is an extremely challenging issue faced by various real world application domains. This research is targeted at coupling cognitive agent technology and human-centered teamwork to address the informational challenges associated with Command and Control (C2) teams in contemporary military(More)