Shuang Hu

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BACKGROUND Clara cell 10-kDa protein (CC10) is a multifunctional protein with anti-inflammatory and immunomodulatory effects. Induction of CC10 expression by gene transfection may possess potential therapeutic effect. Nuclear factor κB (NF-κB) plays a key role in the inflammatory processes of airway diseases. METHOD/RESULTS To investigate potential(More)
Rho-family GTPases play regulatory roles in many fundamental cellular processes. Caenorhabditis elegans UNC-73 RhoGEF isoforms function in axon guidance, cell migration, muscle arm extension, phagocytosis, and neurotransmission by activating either Rac or Rho GTPase subfamilies. Multiple differentially expressed UNC-73 isoforms contain a Rac-specific(More)
RhoGEF proteins activate the Rho family of small GTPases and thus play a key role in regulating fundamental cellular processes such as cell morphology and polarity, cell cycle progression and gene transcription. We identified a Caenorhabditis elegans RhoGEF protein, RHGF-2, as a binding partner of the C. elegans multi-PDZ domain scaffold protein MPZ-1(More)
Hu, Shuang, "Rho GTPase signaling modulates neurotransmission in Caenorhabditis elegans" (2013). Theses and Dissertations. Paper 100. Rho family GTPases act as molecular switches in the regulation of diverse cellular functions, including cell division, gene transcription and neurotransmission. In the model organism Caenorhabditis elegans, the Kalirin and(More)
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