Picrasidine N Is a Subtype-Selective PPARβ/δ Agonist.
- Shuai Zhao, Yuichiro Kanno, Huicheng Li
- Biology, ChemistryJournal of Natural Products
- 30 March 2016
The naturally occurring dimeric alkaloid picrasidine N from Picrasma quassioides was identified as a novel PPARβ/δ agonist from a library consisting of plant extracts and natural compounds using a mammalian one-hybrid assay, and this compound was characterized.
Androgen receptor functions as a negative transcriptional regulator of DEPTOR, mTOR inhibitor.
- Yuichiro Kanno, Shuai Zhao, Naoya Yamashita, K. Yanai, K. Nemoto, Y. Inouye
- Biology, ChemistryJournal of Toxicological Sciences
- 1 December 2015
It is proposed that AR-dependent prostate cancer cell proliferation requires decreased DEPTOR transcription directly controlled by AR, a naturally occurring inhibitor of mTOR.
Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells.
- Shuai Zhao, Yuichiro Kanno, Momoka Nakayama, Minami Makimura, S. Ohara, Y. Inouye
- Chemistry, BiologyCancer Letters
- 28 April 2012
HER2 overexpression-mediated inflammatory signaling enhances mammosphere formation through up-regulation of aryl hydrocarbon receptor transcription.
- Shuai Zhao, S. Ohara, Y. Inouye
- Biology, ChemistryCancer Letters
- 1 March 2013
Heregulin‐induced cell migration is promoted by aryl hydrocarbon receptor in HER2‐overexpressing breast cancer cells
- Naoya Yamashita, Nao Saito, Yuichiro Kanno
- Biology, ChemistryExperimental Cell Research
- 1 May 2018
Picrasidine G decreases viability of MDA-MB 468 EGFR-overexpressing triple-negative breast cancer cells through inhibition of EGFR/STAT3 signaling pathway.
- Naoya Yamashita, Manami Kondo, Yuichiro Kanno
- BiologyBioorganic & Medicinal Chemistry Letters
- 1 June 2017
Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor.
- Yuichiro Kanno, Tomofumi Yatsu, K. Koike
- Biology, MedicinePhytomedicine
- 15 March 2017
Identification of Picrasidine C as a Subtype-Selective PPARα Agonist.
- Shuai Zhao, Yuichiro Kanno, Huicheng Li
- Biology, ChemistryJournal of Natural Products
- 13 December 2016
This is the first report to demonstrate 1 to be a subtype-selective PPARα agonist with potential application in treating metabolic diseases, such as hyperlipidemia, atherosclerosis, and hypercholesterolemia.
Interfering effects on the bioactivities of several key proteins of COVID-19/variants in diabetes by compounds from Lianqiao leaves: In silico and in vitro analyses
- Yishan Fu, Fei Pan, Lei Zhao, Shuai Zhao, Junjie Yi, Shengbao Cai
- BiologyInternational Journal of Biological…
- 1 March 2022
Differences in Gene Regulation by Dual Ligands of Nuclear Receptors Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) in HepG2 Cells Stably Expressing CAR/PXR
- Yuichiro Kanno, N. Tanuma, Y. Inouye
- BiologyDrug Metabolism And Disposition
- 1 August 2016
The results suggest that dual ligands of CAR/PXR show distinct gene regulation patterns by cross-talk between CAR and PXR.
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