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Identification of chalcone isomerase in the basal land plants reveals an ancient evolution of enzymatic cyclization activity for synthesis of flavonoids.
TLDR
These findings, in contrast to the current understanding of the evolution of enzymatic CHIs, suggest that emergence of the bona fide type II CHIs is an ancient evolution event that occurred before the divergence of liverwort lineages.
Enzymatic production of oroxylin A and hispidulin using a liverwort flavone 6‐O‐methyltransferase
TLDR
The gene encoding an O‐methyltransferase (designated PaF6OMT) was isolated from the liverwort species Plagiochasma appendiculatum and its strongest preferences were baicalein and scutellarein, which were converted into oroxylin A and hispidulin.
Functional characterization of a chalcone synthase from the liverwort Plagiochasma appendiculatum
TLDR
The cloning and characterization of CHS (designated as PaCHS) from the liverwort Plagiochasma appendiculatum was isolated and functionally characterized, the first time that a chalcone synthase gene in liverworts has been functionally characterized.
PXD101 analogs with L‐phenylglycine‐containing branched cap as histone deacetylase inhibitors
TLDR
The design, synthesis, and in vitro activity evaluation of novel PXD101 analogs with L‐phenylglycine‐containing cap as HDACIs showed that HDACs inhibitory activities of compounds 10k, 10r, and 10s were not only superior to the first approved HDACI SAHA, but also comparable to their parent compound PxD101.
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