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Cx43 reverses the resistance of A549 lung adenocarcinoma cells to cisplatin by inhibiting EMT.
TLDR
Cx43 reverses CDDP resistance in A549 CDDP-resistant cells by preventing EMT, making Cx43 a possible therapeutic target for lung cancer. Expand
Suppression of PMA-induced tumor cell invasion and migration by ginsenoside Rg1 via the inhibition of NF-κB-dependent MMP-9 expression
TLDR
The results suggested that the anticancer properties of ginsenoside Rg1 may derive from its ability to inhibit invasion and migration, and that these processes are regulated in breast cancer cells through the NF-κB-mediated regulation of MMP-9 expression. Expand
JAK2/STAT3 pathway is involved in the protective effects of epidermal growth factor receptor activation against cerebral ischemia/reperfusion injury in rats
TLDR
It is implicate that JAK2/STAT3 pathway plays the vital role in I/R injury protection from activating EGFR, and the neuroprotective effects may associate with inhibiting the Cx43 expression and the inhibition of apoptosis. Expand
Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF‑κB.
TLDR
Observations indicate that berberine inhibits NF‑κB activation and may be used to enhance CPT‑11‑induced apoptosis in colon cancer. Expand
In vitro inhibited effect of gap junction composed of Cx43 in the invasion and metastasis of testicular cancer resistanced to cisplatin.
TLDR
GJ composed of Cx43 inhibits I-10/DDP cells invasion and migration, and it may become the potential therapeutic target for testicular cancer chemotherapy. Expand
Influence of gap junction intercellular communication composed of connexin 43 on the antineoplastic effect of adriamycin in breast cancer cells.
TLDR
The cytotoxicity of adriamycin on breast cancer cells was increased when the function of gap junctions was enhanced and the modulation of GJ did not affect the survival of cells treated with adRIamycin when cells were in low density. Expand
Role of gap junction intercellular communication in testicular leydig cell apoptosis induced by oxaliplatin via the mitochondrial pathway.
TLDR
In testicular leydig normal/cancer cells, GJIC plays an opposite role in oxaliplatin‑induced apoptosis via the mitochondrial pathway, which is correlated with the mitochondrial pathways-related protein Bcl-2/Bax and caspase‑3/9. Expand
Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.
TLDR
Gefitinib enhanced oxaliplatin-induced apoptosis in I-10 cells and gefit inib upregulated the GJIC by inhibiting Src and PKC-modulated Cx43 phosphorylation, demonstrating the synergistic influence of these drugs in testicular cancer chemotherapy. Expand
[Expression of connexin 43 and functional modulation of gap junction in neonatal rat astrocytes in vitro].
TLDR
ATRA and oleamide can modulate gap junction intercellular communication of the astrocytes possibly by regulating the expression of Cx43 protein. Expand
Role of heteromeric gap junctions in the cytotoxicity of cisplatin.
TLDR
Heteromeric Cx26/Cx32 gap junctions increase the cytotoxicity of cisplatin by induction of apoptosis via the mitochondrial pathway and is demonstrated to be more selective among biological permeants than the corresponding homomeric channels. Expand
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