Learn More
BACKGROUND Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases. While AT1R blockade has been extensively studied, the potential of targeting the antagonistically acting AT2R in cancer has not been investigated. This study examined the effect of AT2R(More)
BACKGROUND Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could result in synergistic inhibition of colorectal cancer (CRC) liver metastases. METHODS Immediately following induction of CRC liver(More)
Correction After publication of this work [1], we noted that we inadvertently failed to properly acknowledge all of our funding agencies. The acknowledgements section has now been modified accordingly. PhD Scholarship. We would like to thank Professor Mauro Sandrin and his team from the xenotransplantation group at Austin Health (Australia), Dr Russell(More)
  • 1