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Crystal Structure of an IHF-DNA Complex: A Protein-Induced DNA U-Turn
The crystal structure of IHF complexed with 35 bp of DNA is reported, providing evidence for the importance of a narrow minor groove in IHF's binding sequence. Expand
Chemokine receptor CCR-5 inhibitors produced by Chaetomium globosum.
Two novel chemokine receptor CCR-5 inhibitors were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications and the structure and relative configuration of 2 were determined unequivocally by X-ray crystallographic analysis. Expand
Structure elucidation of a new antifungal sterol sulfate, Sch 575867, from a deep-water marine sponge (Family: Astroscleridae).
It is described as a red-orange, rock hard, 15cm spherical sponge, with a thin veneer of living tissue over an aragonite skeleton, which is porous and smooth, with 2cm diameter mounds. Expand
Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
Two pyrazoloquinoline analogs, compounds 16 and 27, were found to possess potent oral antipsychotic activity in the MK-801 induced hyperactive rat model. Expand
TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci
  • Sang Ho Lee, Hao Wang, +29 authors T. Roemer
  • Medicine
  • Science Translational Medicine
  • 9 March 2016
Tarocins and other inhibitors of wall teichoic acid biosynthesis may provide a rational strategy to develop Gram-positive bactericidal β-lactam combination agents active against methicillin-resistant staphylococci. Expand
A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp.
Bioassay-guided fractionation of an active fraction from a marine sponge Topsentia sp. in our marine fraction library (MFL) led to the isolation and identification of halistanol sulfate (1) and a newExpand
A New Hydrogenated Azaphilone Sch 725680 from Aspergillus sp.
Compound 1 showed inhibitory activity against Saccharomyces cerevisiae and Candida albicans with MICs of 8 and 64 μg/ml, respectively, and was elucidated based on extensive NMR spectroscopic analyses. Expand
Structure elucidation of a new diketopiperazine Sch 725418 from Micromonospora sp.
The isolation and structure elucidation of a novel diketopiperazine, Sch 725418 (1), is described using high resolution ESI-MS and extensive NMR spectroscopic analysis. Expand
Sch 1385568, a new azaphilone from Aspergillus sp.
The fermentation, isolation, structure elucidation and antimicrobial activity of a novel azaphilone Sch 1385568 from an Aspergillus sp. Expand