Shu-min Zhao

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Epigenetic, which refers to heritable differences of genes without changing their DNA sequences, is one of the most important biology phenomena in multicellular eukaryotes. Its research contents involves DNA methylation, genomic imprinting, histone acetylation, histone methylation, chromatin remodeling, pseudogene, and microRNA etc. Monozygotic twins is(More)
OBJECTIVE To develop a PCR-based X-STR kit for typing of 16 X-STR loci and investigate the polymorphisms of the X-STR markers. METHODS Sixteen STR loci (GATA 165B12, DXS101, GATA 172D05, HPRTB, DXS981, DXS8378, DXS6795, GATA 31E08, DXS6809, DXS6803, DXS9902, DXS6807, DXS7423, DXS7133, DXS6810 and DXS7132) located on X chromosome were selected. The primers(More)
We investigate the muon anomalous magnetic dipole moment (MDM), the muon electric dipole moment (EDM) and the lepton-flavour-violating decays of the τ−lepton, τ → μγ and τ → 3μ, in the CP-violating Minimal Supersymmetric Standard Model (MSSM) with nonuniversal softsupersymmetry breaking. We evaluate numerically the muon EDM and the branching ratios B(τ →(More)
OBJECTIVE To establish and evaluate the method of matched locus numbers in full sibling identification. METHODS Two hundred and eighty full sibling (FS) pairs and 2003 unrelated individual (UI) pairs were genotyped with Identifiler system. The number of locus matched with 0 identical allele (A0), matched with 1 allele (A1) or matched with 2 alleles (A2)(More)
OBJECTIVE To investigate the criterion for source identification of gastrointestinal tumor based on the number of identical allele (IAn) and the number of matched STR locus with 2 identical alleles (A2) in Identifiler system. METHODS One hundred and five pairs of gastrointestinal tumor samples and homologous normal samples (TN group) were genotyped with(More)
OBJECTIVE To develop a rapid, accurate and economical real time fluorescence PCR method with TaqMan probe technology to detect the X chromosome single nucleotide polymorphism (X-SNP). METHODS TaqMan probes and polymerase chain reaction primers were respectively designed according to the 13 X-SNP. Then, the X-SNP were genotyped after the amplification by(More)
OBJECTIVE To study the effect of urinary trypsin inhibitor (UTI) on STR genotyping with urinary samples. METHODS Midstream urine samples of 5 male and 5 female volunteers were collected respectively, sub-packaged, added with different concentration of UTI and stored at -80 degrees C. Genomic DNA was extracted from those urinary samples, of which STR(More)
OBJECTIVE To establish universal algorithms for commonly used kinship indices between two individuals. METHODS Based on the formulas of paternity index in duos(PID), full sibling index(FSI), half sibling index (HSI), avuncular index (AI), grandparental index (GI) and first cousin index (CI1st) deduced from ITO method, the common factors, 1 plus reciprocal(More)
OBJECTIVE To evaluate the applicability of partial loss of heterozygous (pLOH) criteria in tumor tissues with Identifiler system. METHODS Eight thousand four hundred and twenty eight heterozygous loci of the 696 unrelated individuals (UIP) genotyped with Identifiler Kit were randomly paired by locus to construct odds ratio of allelic peak height (or area(More)
OBJECTIVE Determination strategies for half sibling sharing a same mother were investigated through the detection of autosomal and X-chromosomal STR (X-STR) loci and polymorphisms on hypervariable (HV) region of mitochondrial DNA (mtDNA). METHODS Genomic DNA were extracted from blood stain samples of the 3 full siblings and one dubious half sibling(More)