Shu-hui Zhang

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Communication between cells by release of specific chemical messengers via exocytosis plays crucial roles in biological process. Electrochemical detection based on ultramicroelectrodes (UMEs) has become one of the most powerful techniques in real-time monitoring of an extremely small number of released molecules during very short time scales, owing to its(More)
In order to improve the dissolution and absorption of the water insoluble drug repaglinide, a solid dispersion was developed by solvent method using polyvinylpyrrolidone K30 (PVP K30) as the hydrophilic carrier for the first time. Studies indicated that both solubility and the dissolution rate of repaglinide were significantly increased in the solid(More)
Chemical synaptic transmission is central to the brain functions. In this regard, real-time monitoring of chemical synaptic transmission during neuronal communication remains a great challenge. In this work, in vivo-like oriented neural networks between superior cervical ganglion (SCG) neurons and their effector smooth muscle cells (SMC) were assembled in a(More)
Chemical neurotransmission occurs at chemical synapses and endocrine glands, but up to now there was no means for direct monitoring of neurotransmitter exocytosis fluxes and their precise kinetics from inside an individual synapse. The fabrication of a novel finite conical nanoelectrode is reported perfectly suited in size and electrochemical properties for(More)
Electrochemical techniques based on ultramicroelectrodes (UMEs) play a significant role in real-time monitoring of chemical messengers' release from single cells. Conversely, precise monitoring of cells in vitro strongly depends on the adequate construction of cellular physiological microenvironment. In this paper, we developed a multilayer microdevice(More)
The ubiquity of environmental pollution by endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) is progressively considered as a major threat to aquatic ecosystems worldwide. Numerous toxicological studies have proved that BPA are hazardous to aquatic environment, along with alterations in the development and physiology of aquatic vertebrates.(More)
Oxidative bursts from plants play significant roles in plant disease defense and signal transduction; however, it has not hitherto been investigated on individual living plant cells. In this article, we fabricated a novel sensitive electrochemical sensor based on electrochemical deposition of Pt nanoparticles on the surface of carbon fiber microdisk(More)
The spatio-temporal trend of ecosystem services value change along the profile of landscape heterogeneity of mountain-basin system (MBS) in the north slope of Tianshan Mountain during 1988 to 2003 was analyzed based on the data of land use/cover change (LUCC), taking Manas County as an example. Results showed that the total value of ecosystem services of(More)
Based on the land use/cover data of 1995 and 2004, and by using ecosystem service value per unit area of different terrestrial ecosystem types in China, the dynamic changes of ecosystem service value in Pinggu District of Beijing were analyzed. The results showed that the total ecosystem service value of Pinggu District was decreased from 3.291 x 10(9) yuan(More)
The adjustment of the industrial structure in metropolis emergency water source reserve correlates the safety of drinking water. The industrial agglomeration is an important basis for the adjustment of the industrial structure and layout. Taking the manufacturing industries in Pinggu District, Beijing City as an example, and using three indicators, which(More)