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GOLPH3 Overexpression is Closely Correlated with Poor Prognosis in Human Non-Small Cell Lung Cancer and Mediates its Metastasis Through Upregulating MMP-2 and MMP-9
TLDR
The expression level of GOLPH3 is correlated with metastasis and prognosis in NSCLC, and GolPH3 mediates metastasis by regulating the protein levels of MMP-2 and MMP -9 in vitro. Expand
Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis
TLDR
Mechanistic studies conducted in vitro and in vivo revealed that AEG-1-mediated carcinogenesis and invasiveness might be through upregulating MMP-2, and A EG-1 could be a useful biomarker for the prediction of osteosarcoma progression and prognosis. Expand
SRF-miR‑29b-MMP2 axis inhibits NSCLC invasion and metastasis.
TLDR
Findings indicate a new regulatory mode, whereby miR‑29b, which is inhibited by its upstream transcription factor SRF, was able to promote its direct target MMP2 leading to NSCLC invasion and metastasis. Expand
[The roles of caveolin-1 and endothelial nitric oxide synthase in the development of portal hypertension in rats with liver cirrhosis].
TLDR
Caveolin-1 upregulation is associated with the development of portal hypertension in liver cirrhosis and over-expression of caveolin- 1 in perisinusoidal cells may promote caveolin -1-eNOS binding and reduce the activity of eNOS. Expand
[Adeno-associated virus mediated tumor necrosis factor related apoptosis inducing ligand gene transfected into hepatocellular carcinoma cells by ultrasound microbubble intensifier: an experimental
TLDR
Trail has a potential role to inhibit e proliferation and induce apoptosis of human hepatocellular carcinoma cells and was found to increase the transfection rate of rAAV vector into HCC cells. Expand
[Influence of liver regeneration after partial hepatectomy on the development of liver metastasis of colon cancer in rats].
TLDR
PH may accelerate the growth of residual microscopic tumor in the liver which contributes to local recurrence and has no systemic effect and effects on the cancer cell lines in extrahepatic sites. Expand
[Experimental study of NK4 gene targeted therapy mediated by human telomerase reverse transcriptase promoter for colon cancer].
TLDR
Ad HTERTp-NK4 can inhibit tumor growth and decrease the invasive capacity of tumor cells, which makes it an ideal candidate for new gene therapy for colon carcinoma. Expand