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UNLABELLED c-Myc is a well-known oncogene frequently up-regulated in different malignancies, whereas liver-specific microRNA (miR)-122, a bona fide tumor suppressor, is down-regulated in… Continue Reading
Clinical application of small interfering RNA (siRNA) requires safe and efficient delivery in vivo. Here, we report the design and synthesis of lipid nanoparticles (LNPs) for siRNA delivery based on… Continue Reading
The composition of the liver changes dramatically with age. Hepatocytes in young individuals are relatively small and uniform in size. In contrast, adult hepatocytes vary considerably in cell and… Continue Reading
BackgroundOxidative stress is a major factor in retinal pigment epithelium (RPE) cells injury that contributes to age-related macular degeneration (AMD). NaIO3 is an oxidative toxic agent and its… Continue Reading
After the publication of this article , the authors would like to clarify that some immunoblotting data in Figs. 2f, 3a and 4b were obtained from the same samples but individual SDS-PAGE gels.
A defining feature of the mammalian liver is polyploidy, a numerical change in the complement of chromosomes. Hepatocytes are either mono- or binucleate, and ploidy is determined by the number of… Continue Reading
Background: miR-122 is the most abundant liver-specific microRNA that modulates hepatic lipid metabolism, hepatitis C viral replication and is downregulated in hepatocellular carcinoma (HCC) of both… Continue Reading
Although the mechanism and functional significance of high levels of aerobic glycolysis in cancer cells (Warburg effect) have been extensively studied, the possibility of altered gluconeogenesis that… Continue Reading