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NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways
Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G.
- K. Luo, Zuoxiang Xiao, Xiao-Fang Yu
- BiologyProceedings of the National Academy of Sciences…
- 9 August 2005
It is demonstrated that primate lentiviral Vif (virion infectivity factor) proteins represent previously uncharacterized substrate receptor proteins that contain divergent BC-box motifs, which suggest that in addition to target protein specificity, substrate receptors proteins play important roles in cullin selection and functional assembly of cullin-Ring E3 ligases.
CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.
Berbamine is identified as a specific and critical target of berbamine for its antileukemia activity and may be the first ATP-competitive inhibitor of CaMKII γ, and potentially, can serve as a new type of molecular targeted agent through inhibition of the CaMK II γ activity for treatment of leukemia.
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.
It is proposed that aberrantly increased expression of Shp2 may contribute, collaboratively with other factors, to leukemogenesis.
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma
- R. Xu, Xuzhao Zhang, Wei Zhang, Yong-ming Fang, Shu Zheng, Xiao-Fang Yu
- Biology, MedicineHepatology
- 1 December 2007
Findings suggest that some of the APOBEC3 deaminases play a role in the carcinogenesis of HCC through the generation of HBx mutants, providing preneoplastic and neoplastic hepatocytes with a selective clonal growth advantage.
Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression
A3B suppresses HBV replication in hepatocytes by inhibiting hnRNP K‐mediated transcription and expression of HBV genes as well as HBV core DNA synthesis, suggesting A3B protein may be a broad antiviral host factor.
ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68.
Expression Patterns of Non-Coding Spliced Transcripts from Human Endogenous Retrovirus HERV-H Elements in Colon Cancer
Besides the commonly accepted view of up-regulation of HERV-H expression in colon tumor tissues, this is the first research to study the character of expression of non-coding spliced transcripts of HERv-H elements in colon cancer.
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins
This study identified SARS-CoV-2 structural proteins, accessory proteins, and the main viral protease as potent inhibitors of host innate immune responses of distinct pathways, and provides insights into the design of therapeutic agents against Sars-Cov-2.
The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers
- Qiao-yi Liang, Jia-yi Ding, R. Xu, Ze-feng Xu, Shu Zheng
- BiologyInternational journal of cancer
- 15 October 2010
Results suggest psiTPTE22‐HERV is regulated epigenetically by DNA methylation, which paved the way for further study on an interesting HERV‐related human‐specific gene, which is silenced in cancers byDNA methylation.