Skip to search formSkip to main contentSkip to account menu
NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways
View on Elsevier
Primate lentiviral virion infectivity factors are substrate receptors that assemble with cullin 5-E3 ligase through a HCCH motif to suppress APOBEC3G.
TLDR
It is demonstrated that primate lentiviral Vif (virion infectivity factor) proteins represent previously uncharacterized substrate receptor proteins that contain divergent BC-box motifs, which suggest that in addition to target protein specificity, substrate receptors proteins play important roles in cullin selection and functional assembly of cullin-Ring E3 ligases.
View on PubMed
CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.
TLDR
Berbamine is identified as a specific and critical target of berbamine for its antileukemia activity and may be the first ATP-competitive inhibitor of CaMKII γ, and potentially, can serve as a new type of molecular targeted agent through inhibition of the CaMK II γ activity for treatment of leukemia.
View on PubMed
Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia.
TLDR
It is proposed that aberrantly increased expression of Shp2 may contribute, collaboratively with other factors, to leukemogenesis.
View on PubMed
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma
TLDR
Findings suggest that some of the APOBEC3 deaminases play a role in the carcinogenesis of HCC through the generation of HBx mutants, providing preneoplastic and neoplastic hepatocytes with a selective clonal growth advantage.
View on Wiley
Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression
TLDR
A3B suppresses HBV replication in hepatocytes by inhibiting hnRNP K‐mediated transcription and expression of HBV genes as well as HBV core DNA synthesis, suggesting A3B protein may be a broad antiviral host factor.
View on Wiley
ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68.
View on PubMed
Expression Patterns of Non-Coding Spliced Transcripts from Human Endogenous Retrovirus HERV-H Elements in Colon Cancer
TLDR
Besides the commonly accepted view of up-regulation of HERV-H expression in colon tumor tissues, this is the first research to study the character of expression of non-coding spliced transcripts of HERv-H elements in colon cancer.
View PDF
Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins
TLDR
This study identified SARS-CoV-2 structural proteins, accessory proteins, and the main viral protease as potent inhibitors of host innate immune responses of distinct pathways, and provides insights into the design of therapeutic agents against Sars-Cov-2.
View on Springer
The novel human endogenous retrovirus‐related gene, psiTPTE22‐HERV, is silenced by DNA methylation in cancers
TLDR
Results suggest psiTPTE22‐HERV is regulated epigenetically by DNA methylation, which paved the way for further study on an interesting HERV‐related human‐specific gene, which is silenced in cancers byDNA methylation.
View on Wiley
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License