Shu-Yu Sun

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Voltage-gated calcium channel (Ca(v))2.2 (N-type calcium channels) are key components in nociceptive transmission pathways. Ziconotide, a state-independent peptide inhibitor of Ca(v)2.2 channels, is efficacious in treating refractory pain but exhibits a narrow therapeutic window and must be administered intrathecally. We have discovered an N-triazole(More)
Explicit a posteriori residual type error estimators in L 2 (H 1) norm are derived for discontinuous Galerkin (DG) methods applied to transport in porous media with general kinetic reactions. They are flexible and apply to all the four primal DG schemes, namely, Oden–Babuška–Baumann DG (OBB-DG), non-symmetric interior penalty Galerkin (NIPG), symmetric(More)
Primal discontinuous Galerkin methods with interior penalty are proposed to solve the coupled system of flow and reactive transport in porous media, which arises from many applications including miscible displacement and acid-stimulated flow. A cutoff operator is introduced in the discontinuous Galerkin schemes to treat the coupling of flow and transport(More)
Acknowledgments First I would like to thank my supervisor, Professor Mary F. Wheeler, for her support and supervision. She has guided my studies and encouraged my work in computational and applied science and engineering. She has not only mentored me academically as a researcher; she has also taught me valuable life lessons. All the work done in this(More)
Astragalus polysaccharides (APS) possess multiple immunomodulatory activities. Due to its high molecular weight, orally administration of APS is not easily absorbed into the blood stream, and how APS exerts its capacity in vivo is still not well elucidated. We assume that enteric mucosal immune response might trigger the immune regulation of APS, and our(More)
Explicit a posteriori residual type error estimators in energy norm are derived for four primal DG schemes (i.e. OBB-DG, NIPG, SIPG and IIPG) applied to transport in porous media with general kinetic reactions. A poste-riori error estimators proposed here use directly all the available information from the numerical solution, and can be computed(More)
IMplicit Pressure Explicit Saturation (IMPES) scheme with treating buoyancy and capillary forces is used to solve the two-phase water-CO 2 flow problem. In most of the previous studies of the two-phase flow, the buoyancy force term was ignored; however, in the case of liquid-gas systems such as water-CO 2 , the gravity term is very important to express the(More)
Discontinuous Galerkin (DG) methods are formulated to solve contaminant transport problems. Error indicators-guided dynamic mesh adaptation strategies are presented for efficient DG implementations. Numerical results demonstrate that the dynamic approaches can resolve time-dependent contaminant transport adequately without slope limiting; in particular, the(More)
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