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S phase kinase-associated protein 2 (Skp2), an F-box protein, is required for the ubiquitination and consequent degradation of p27kip1. Previous reports have showed that p27kip1 played important roles in cell cycle regulation and neurogenesis in the developing central nervous system. But the distribution and function of p27kip1 and Skp2 in nervous system(More)
Nitric oxide and nitric oxide synthases are key players in synaptic plasticity events in spinal cord (SC), which underlies the chronic pain states. To date, little is known about the molecular mechanisms regulating the activity of nitric oxide synthases in nociceptive systems. The present study was aimed at the determination of the gene expression of(More)
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