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Galectin-1 (GAL1), a widely expressed β‑galacto-side-binding protein, exerts pleiotropic biological functions. GAL1 has been found to be upregulated in many malignancies; yet the role of GAL1 in the pathophysiology of human osteosarcoma (OS) remains uncertain. The present study was carried out to investigate the expression of GAL1 in human OS tissues and to(More)
BACKGROUND Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. METHODS We analyzed liver X receptor α (LXRα) mRNA expression in 16 pairs of human osteosarcoma tissues and adjacent noncancerous tissues. Moreover, we investigated LXRα's potential role in regulating cell proliferation in Saos-2 and U2OS cells. RESULTS(More)
A key challenge in the post genome era is to identify genome-wide transcriptional regulatory networks, which specify the interactions between transcription factors and their target genes. In this work, a regulatory model-based binding energy is proposed to quantify the transcriptional regulatory network. Multiple quantities, including binding affinity,(More)
The main purpose of this paper is to analyze the variational iteration method for solving the two-point boundary value problems. We show that Wang [Shu-Qjang Wang, A variational approach to nonlinear two-point boundary value problems, Comput. Math. Appl. 58 (2009) 2452-2455] demonstrated some incorrect solutions for two-point boundary value problems studied(More)
PURPOSE To investigate the use of a newly designed machine learning-based classifier in the automatic identification of myelopathic levels in cervical spondylotic myelopathy (CSM). MATERIALS AND METHODS In all, 58 normal volunteers and 16 subjects with CSM were recruited for diffusion tensor imaging (DTI) acquisition. The eigenvalues were extracted as the(More)
A key challenge in the post genome era is to identify genome-wide transcriptional regulatory networks, which specify the interactions between transcription factors and their target genes. Numerous methods have been developed for reconstructing gene regulatory networks from expression data. However, most of them are based on coarse grained qualitative(More)
Diffusion tensor image (DTI) of the cervical spinal cord has been proposed to be used to identify the myelopathic level in the cervical spinal cord. Fractional anisotropy (FA) from DTI is usually used to diagnose the level of cervical spondylotic myelopathy (CSM). However, the solely use of FA value does not consider a full information of 3D multiple(More)
BACKGROUND Chronic kidney disease (CKD) has become a public health problem. New interventions to slow or prevent disease progression are urgently needed. In this setting, cell therapies associated with regenerative effects are attracting increasing interest. We evaluated the effect of embryonic stem cells (ESCs) on the progression of CKD. METHODS Adult(More)