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Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and longevity, effects that require the IIS-inhibited FOXO protein DAF-16. The C. elegans transcription factor SKN-1 also defends against oxidative stress by mobilizing the conserved phase 2(More)
PURPOSE To evaluate the reproducibility of anterior chamber angle measurements obtained by swept-source optical coherence tomography (OCT) and to identify factors associated with its measurement variability. METHODS One eye from each of 30 healthy subjects was randomly selected for anterior segment OCT imaging (Casia SS-1000 OCT; Tomey, Nagoya, Japan) in(More)
BACKGROUND Any organism depends on its ability to sense temperature and avoid noxious heat. The nematode Caenorhabditis elegans responds to noxious temperatures exceeding ∼35°C and also senses changes in its environmental temperature in the range between 15 and 25°C. The neural circuits and molecular mechanisms involved in thermotaxis have been successfully(More)
Wireless network providers are under tremendous pressure to deliver unprecedented amounts of data to a variety of mobile devices. A powerful concept that has only gained limited traction in practice has been the concept of opportunistic networks whereby nodes opportunistically communicate with each other when in range to augment or overcome existing(More)
The availability of “always-on” communications has tremendous implications for how people interact socially. In particular, sociologists are interested in the question if such pervasive access increases or decreases face-to-face interactions. Unlike triangulation which seeks to precisely define position, the question of face-to-face(More)
PURPOSE To investigate the longitudinal profiles of microgliosis after optic nerve injury induced by optic nerve crush and acute elevation of intraocular pressure (IOP). METHODS A confocal scanning laser ophthalmoscope was used to image the retinal microglia of the CX3CR1(GFP/+) transgenic mice in vivo at baseline, 3 days and then weekly for 4 weeks after(More)
Aiming at simultaneous detection and segmentation (SD-S), we propose a proposal-free framework, which detect and segment object instances via mid-level patches. We design a unified trainable network on patches, which is followed by a fast and effective patch aggregation algorithm to infer object instances. Our method benefits from end-to-end training.(More)
PURPOSE To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis. METHODS One hundred sixteen eyes of 64 patients with glaucoma who were observed within a period of 5 years were included. All eyes had at least four serial RNFL measurements obtained with the Stratus OCT (Carl(More)
Over the past few years, smartphones have emerged as one of the most popular mechanisms for accessing content across the Internet driving considerable research to improve wireless performance. A key foundation for such research efforts is the proper understanding of user behavior. However, the gathering of live smartphone data at scale is often difficult(More)