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Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and longevity, effects that require the IIS-inhibited FOXO protein DAF-16. The C. elegans transcription factor SKN-1 also defends against oxidative stress by mobilizing the conserved phase 2(More)
PURPOSE To investigate the longitudinal profiles of microgliosis after optic nerve injury induced by optic nerve crush and acute elevation of intraocular pressure (IOP). METHODS A confocal scanning laser ophthalmoscope was used to image the retinal microglia of the CX3CR1(GFP/+) transgenic mice in vivo at baseline, 3 days and then weekly for 4 weeks after(More)
BACKGROUND Any organism depends on its ability to sense temperature and avoid noxious heat. The nematode Caenorhabditis elegans responds to noxious temperatures exceeding ∼35°C and also senses changes in its environmental temperature in the range between 15 and 25°C. The neural circuits and molecular mechanisms involved in thermotaxis have been successfully(More)
Wireless network providers are under tremendous pressure to deliver unprecedented amounts of data to a variety of mobile devices. A powerful concept that has only gained limited traction in practice has been the concept of opportunistic networks whereby nodes opportunistically communicate with each other when in range to augment or overcome existing(More)
The availability of “always-on” communications has tremendous implications for how people interact socially. In particular, sociologists are interested in the question if such pervasive access increases or decreases face-to-face interactions. Unlike triangulation which seeks to precisely define position, the question of face-to-face(More)
This paper presents control of doubly fed induction generator for variable speed wind power generation. The control scheme uses stator flux-oriented control for the rotor side converter and grid voltage vector control for the grid side converter. A complete simulation model is developed for the control of the active and reactive powers of the doubly fed(More)
Aiming at simultaneous detection and segmentation (SD-S), we propose a proposal-free framework, which detect and segment object instances via mid-level patches. We design a unified trainable network on patches, which is followed by a fast and effective patch aggregation algorithm to infer object instances. Our method benefits from end-to-end training.(More)
OBJECTIVE To evaluate and compare the diagnostic agreement and performance for glaucoma detection between a confocal scanning laser ophthalmoscope and a spectral-domain optical coherence tomograph (OCT). DESIGN Prospective, cross-sectional study. PARTICIPANTS One hundred fifty-five subjects (79 glaucoma and 76 normal subjects). METHODS One eye from(More)
OBJECTIVE To evaluate and compare the retinal nerve fiber layer (RNFL) measurement variability, diagnostic sensitivity and specificity for glaucoma detection, and strength of the structure-function association obtained with a spectral-domain optical coherence tomography (OCT) device (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) and a time-domain OCT(More)
The genome of the flowering plant Arabidopsis thaliana has five chromosomes. Here we report the sequence of the largest, chromosome 1, in two contigs of around 14.2 and 14.6 megabases. The contigs extend from the telomeres to the centromeric borders, regions rich in transposons, retrotransposons and repetitive elements such as the 180-base-pair repeat. The(More)