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Calorie restriction extends life-span in a wide variety of organisms. Although it has been suggested that calorie restriction may work by reducing the levels of reactive oxygen species produced during respiration, the mechanism by which this regimen slows aging is uncertain. Here, we mimicked calorie restriction in yeast by physiological or genetic means(More)
A cause of aging in yeast is the accumulation of circular species of ribosomal DNA (rDNA) arising from the 100-200 tandemly repeated copies in the genome. We show here that mutation of the FOB1 gene slows the generation of these circles and thus extends life span. Fob1p is known to create a unidirectional block to replication forks in the rDNA. We show that(More)
Early full-term pregnancy is one of the most effective natural protections against breast cancer. To investigate this effect, we have characterized the global gene expression and epigenetic profiles of multiple cell types from normal breast tissue of nulliparous and parous women and carriers of BRCA1 or BRCA2 mutations. We found significant differences in(More)
We overview and summarize the progress of the spectral phase encoded time spreading (SPECTS) optical code division multiple access (O-CDMA) technology. Recent progress included a demonstration of a 320 Gbit/ s ͑32-user ϫ 10 Gbit/ s͒ all-optical passive optical network testbed based on the SPECTS O-CDMA technology and a theoretical prediction of the spectral(More)
Secret sharing schemes allows information to be shared among a group of participants so that all together (or qualified subsets) of participants can recover the information. A visual cryptography scheme (VCS) is a cryptographic technique which allows visual information (e.g. printed text, handwritten notes, and picture) to be encrypted in such a way that(More)
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