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Human Pluripotent Stem Cell-Derived Organoids as Models of Liver Disease.
- Muhammad Nadzim Bin Ramli, Yee-Siang Lim, +19 authors Yun-Shen Chan
- Medicine, ChemistryGastroenterology
- 15 June 2020
A hepatic organoid platform with human cells that can be used to model complex liver diseases, including NASH is developed and gene expression signatures similar to those of liver tissues from patients with NASH are compared.
Differential Responses to Virus Challenge of Laboratory and Wild Accessions of Australian Species of Nicotiana, and Comparative Analysis of RDR1 Gene Sequences
The most striking difference was that plants of a laboratory accession of N. benthamiana RA-4 exhibited hypersensitivity to Yellow tailflower mild mottle tobamovirus infection and died, whereas plants of wild N.benthamiana accessions responded with non-necrotic symptoms.
Low root‐to‐root transmission of a tobamovirus, yellow tailflower mild mottle virus, and resilience of its virions
Root-to-root transmission occurred rarely, and when it occurred plants did not exhibit systemic movement of the virus from the roots to the shoots over a 30-day period, indicating resilience of YTMMV virions.
A virome from ornamental flowers in an Australian rural town
The complete genome of an isolate originally classified as ornithogalum mosaic virus was genetically divergent and differed in polyprotein cleavage motifs, and it is proposed that this isolate represents a distinct species.
Catharanthus mosaic virus: A potyvirus from a gymnosperm, Welwitschia mirabilis.
A virus from a symptomatic plant of the gymnosperm Welwitschia mirabilis Hook was inoculated to a plant of Nicotiana benthamiana where it established a systemic infection and became the first record of a virus from W.mirabilis, the first complete genome sequence of catharanthus mosaic virus determined, and the firstrecord from Australia.
Yellow tailflower mild mottle virus and Pelargonium zonate spot virus co‐infect a wild plant of red‐striped tailflower in Australia
This study provides further evidence that PZSV is present in wild plants in Australia, in this casean indigenous host species, and possible routes by which it invaded Australia are discussed, and it is suggested that YTMMV has the potential to become a pathogen of commercialspecies of Solanaceae.
Evolution of a wild-plant tobamovirus passaged through an exotic host: Fixation of mutations and increased replication
- Shu Hui Koh, Hua Li, K. Sivasithamparam, R. Admiraal, Michael Jones, S. Wylie
- Biology, MedicineVirus evolution
- 1 January 2017
Investigation of the capacity of a solanaceous-infecting tobamovirus from an isolated indigenous flora to adapt to new exotic hosts suggests YTMMV evolution is influenced by host changes.
A novel member of the Tombusviridae from a wild legume, Gompholobium preissii
- Shu Hui Koh, J. Ong, R. Admiraal, K. Sivasithamparam, Michael Jones, S. Wylie
- Biology, MedicineArchives of Virology
- 25 July 2016
The proposed virus, named Gompholobium virus A, and TLV1 are genetically closest to viruses in the genera Alphacarmovirus and Pelarspovirus, family Tombusviridae, but they share features distinguishing them from both groups.
Virosphere in flux: Old and new viruses in an ancient land
- Shu Hui Koh
The continuing invasion by exotic viruses, as evidenced by the discovery in Australia of Catharanthus mosaic virus, demonstrates the failure of quarantine practices to prevent new viruses arriving, thereby posing potential threats to indigenous plants.