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Enhanced filopodium formation and stem-like phenotypes in a novel metastatic head and neck cancer cell model.
TLDR
Gain of Slug expression, filopodium formation and stem-like properties in metastatic HNSCC cells are demonstrated, rendering this model a powerful tool for the development of diagnostic biomarkers and identification of therapeutic targets for H NSCC.
Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification
TLDR
Findings may explain the impaired innate immunity of thalassemic patients with chronic iron overload, suggesting the manipulation of lysosomal function as a novel therapeutic approach.
Real-World Effectiveness of Adjuvant Oxaliplatin Chemotherapy in Stage III Colon Cancer: A Controlled Interrupted Time Series Analysis
TLDR
Among real-world patients with stage III colon cancer, the introduction of oxaliplatin does not yield a significant improvement in survival, and future work should identify the subpopulation(s) of patients who benefit significantly from the addition of oxaloplatin.
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