Shu-Fen Tseng

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Prostate cancer (PCa) becomes lethal when cancer cells develop into castration-resistant PCa (CRPC). Androgen receptor (AR) gene mutation, altered AR regulation, or overexpression of AR often found in CRPC is believed to become one of the key factors to the lethal phenotype. Here we identify Slug, a member of the Snail family of zinc-finger transcription(More)
Upon infection of the gastric epithelial cells, the Helicobacter pylori cytotoxin-associated gene A (CagA) virulence protein is injected into the epithelial cells via the type IV secretion system (TFSS), which is dependent on cholesterol. Translocated CagA is targeted by the membrane-recruited c-Src family kinases in which a tyrosine residue in the(More)
The prevalence of urothelial carcinoma is high in dialysis patients. Radical cystectomy is an invasive procedure for patients with recurrent, multiple, or invasive bladder cancer. However, the prognosis of radical cystectomy in dialysis patients has rarely been reported. This study investigates the long-term outcome of radical cystectomy in dialysis(More)
Radiation therapy (RT) is an effective strategy for the treatment of localized prostate cancer (PCa) as well as local invasion. However, some locally advanced cancers develop radiation resistance and recur after therapy; therefore, the development of radiation-sensitizing compounds is essential for treatment of these tumors. DOC-2/DAB2 interactive protein(More)
OBJECTIVES To analyze outcomes of cases in which we adapted a transvesical ureterectomy technique to remove the distal ureter, including complete removal of the bladder cuff, upon retroperitoneal nephroureterectomy (performed when the diseased native kidney and ureter are ipsilateral to the transplant kidney). METHODS Nineteen cases of upper urinary tract(More)
Altered DAB2IP gene expression often detected in prostate cancer (PCa) is due to epigenetic silencing. In this study, we unveil a new mechanism leading to the loss of DAB2IP protein; an oncogenic S-phase kinase-associated protein-2 (Skp2) as E3 ubiquitin ligase plays a key regulator in DAB2IP degradation. In order to unveil the role of Skp2 in the turnover(More)
Massive open online courses (MOOCs) have recently gained worldwide attention from educational institutes. MOOCs provide a new option for learning, yet measurable learning benefits of MOOCs still need to be investigated. Collecting data of three MOOCs at Yuan Ze University (YZU), this paper intended to classify learning behaviors among 1489 students on the(More)
The study of word frequency has been discussed by linguists, psychologists, and computer scientists. However, the results of these studies cannot be valid unless the corpus is big enough and properly-segmented. This paper observes the distributional information derived from word frequency based on . a 14-million-character corpus of Chinese newspaper (CKIP(More)
With the rapid development and enhancement on Internet technology, the shortage of traditional IPv4 address has been gradually recognized. It is estimated that the IPv4 address pool will be run out during 2022-2028. In order not to impede the diffusion and development of Internet technology, the next generation Internet protocol has been proposed. As we(More)