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Isolation and Characterization of Taiwanese Heterotrophic Microalgae: Screening of Strains for Docosahexaenoic Acid (DHA) Production
TLDR
In this study, 25 heterotrophic microalgal strains were successfully isolated from marine habitats around Taiwan and showed a close phylogenic relationship with the Thraustochytriaceae family according to their 18S rRNA gene sequences.
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Cyclooxygenase-1 and Bicistronic Cyclooxygenase-1/Prostacyclin Synthase Gene Transfer Protect Against Ischemic Cerebral Infarction
TLDR
COX-1–based gene transfer has potential for treating ischemic stroke by augmenting prostacyclin and suppressing leukotriene productions and reducing cerebral infarct volume.
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Anti-inflammatory Activity of 8-Hydroxydaidzein in LPS-Stimulated BV2 Microglial Cells via Activation of Nrf2-Antioxidant and Attenuation of Akt/NF-κB-Inflammatory Signaling Pathways, as Well As…
TLDR
8-OHD, a potent Nrf2 activator, Akt/NF-κB activation suppressor, and COX-2 enzyme inhibitor, may have health-promoting effects for mitigating microglia activation and preventing neuroinflammation.
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Caveolin‐1 facilitates cyclooxygenase‐2 protein degradation
TLDR
The findings suggest that Cav‐1 binds COX‐2 in endoplasmic reticulum (ER) and carries it for degradation via ER associated degradation, and the C‐terminal region of COx‐2 is required for Cav­1 binding and degradation.
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The impact of L-type amino acid transporter 1 (LAT1) in human hepatocellular carcinoma
TLDR
It is demonstrated that LAT1 was overexpressed in HCC and could be served as a potential prognostic marker and Kaplan–Meier curves demonstrated that patients with a high expression of LAT1 have a significantly increased risk of shortened survival time.
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Anti‐atherogenic effect of berberine on LXRα‐ABCA1‐dependent cholesterol efflux in macrophages
TLDR
It is suggested that berberine abrogates the formation of foam cells by macrophages by enhancing LXRα‐ABCA1‐dependent cholesterol efflux.
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Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage.
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Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.
TLDR
Caveolin-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlins-1- and p97 complex-mediated COx-2 ubiquitination, retrotranslocation, and degradation.
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Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.
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Impaired Cd14 and Cd36 Expression, Bacterial Clearance, and Toll-Like Receptor 4-Myd88 Signaling in Caveolin-1-Deleted Macrophages and Mice
TLDR
Cav-1 participates in the regulation of CD14, CD36, Toll-like receptor 4 and myeloid differentiation factor 88 protein expression and is crucial for the immune response of macrophages to bacterial infection.
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