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  • Eleni Tzima, Miguel Angel del Pozo, Sanford J Shattil, Shu Chien, Martin A Schwartz
  • Biology, Medicine
  • The EMBO journal
  • 2001 (First Publication: 3 September 2001)
  • Fluid shear stress is a critical determinant of vascular remodeling and atherogenesis. Both integrins and the small GTPase Rho are implicated in endothelial cell responses to shear but the mechanismsExpand
  • Troy A Hornberger, Wai Keung Chu, Yi Wah Mak, J.-C. Hsiung, Sharon A Huang, Shu Chien
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2006 (First Publication: 21 March 2006)
  • Signaling by the mammalian target of rapamycin (mTOR) has been reported to be necessary for mechanical load-induced growth of skeletal muscle. The mechanisms involved in the mechanical activation ofExpand
  • Kenneth R Chien, Kirk U. Knowlton, Huan-zhang Zhu, Shu Chien
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1991 (First Publication: 1 December 1991)
  • Studies from both in vivo and in vitro model systems have provided an initial skeleton of the potential signaling pathways that might regulate cardiac genes during growth and hypertrophy. One of theExpand
  • Eleni Tzima, Miguel Angel del Pozo, +4 authors Martin A Schwartz
  • Biology, Medicine
  • The EMBO journal
  • 2002 (First Publication: 16 December 2002)
  • Hemodynamic shear stress is a fundamental determinant of vascular remodeling and atherogenesis. Changes in focal adhesions, cytoskeletal organization and gene expression are major responses ofExpand