Shu Cheng

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Akt (also called protein kinase B-PKB) is a key component of the phosphoinositide-3-kinase signaling pathway, which is responsible for cell proliferation and survival and is a novel target for antioncogenic indications. In its fully activated state, Akt is phosphorylated on the activation loop (A-loop) at residue Thr 309. We used molecular dynamics (MD)(More)
BACKGROUND Burkitt leukemia/lymphoma is a major subtype of aggressive B-cell lymphoma. Biological targeted therapies on this disease need to be further investigated and may help to improve the clinical outcome of the patients. METHODS This study examined the anti-tumor activity of the histone deacetylases (HDAC) inhibitor valproic acid (VPA) combined with(More)
Understanding hepatic zonation is important both for liver physiology and pathology. There is currently no effective systemic chemotherapy for human hepatocellular carcinoma (HCC) and its pathogenesis is of special interest. Genomic and proteomic data of HCC cells in different culture models, coupled to pathway-based analysis, can help identify HCC-related(More)
The study of diseased human cells and of cells isolated from the natural environment will likely be revolutionized by single cell genomics (SCG). Here, we used protein similarity networks to explore within- and between-cell DNA differences from SCG data derived from six individual rhizarian cells related to Paulinella ovalis and proteins from the complete(More)
BACKGROUND Peripheral T-cell lymphomas (PTCLs) are often aggressive tumors and resistant to conventional chemotherapy. Dysregulation of extrinsic apoptosis plays an important role on tumor cell sensitivity to chemotherapeutic agents. Cellular FLICE inhibitory protein (c-FLIP) is a key regulator of extrinsic apoptotic pathway. METHODS c-FLIP expression was(More)
The Great Oxidation Event (GOE) ∼2.4 billion years ago resulted from the accumulation of oxygen by the ancestors of cyanobacteria [1-3]. Cyanobacteria continue to play a significant role in primary production [4] and in regulating the global marine and limnic nitrogen cycles [5, 6]. Relatively little is known, however, about the evolutionary history and(More)
BACKGROUND Diffuse large B cell lymphoma (DLBCL) represents the most common histological subtype of primary gastrointestinal lymphoma and is a heterogeneous group of disease. Prognostic characterization of individual patients is an essential prerequisite for a proper risk-based therapeutic choice. METHODS Clinical and pathological prognostic factors were(More)
FreeRTOS is an open-source real-time microkernel that has a wide community of users. We present the formal specification of the behaviour of the task part of FreeRTOS that deals with the creation, management, and scheduling of tasks using priority-based preemption. Our model is written in the Z notation, and we verify its consistency using the Z/Eves(More)
Ancient transitions, such as between life that evolved in a reducing versus an oxidizing atmosphere precipitated by the Great Oxygenation Event (GOE) ca. 2.4 billion years ago, fundamentally altered the space in which prokaryotes could derive metabolic energy. Despite fundamental changes in Earth's redox state, there are very few comprehensive,(More)