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Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution
TLDR
Global translation initiation sequencing is presented, applying in parallel the ribosome E-site translation inhibitors lactimidomycin and cycloheximide to achieve simultaneous detection of both initiation and elongation events on a genome-wide scale.
Decoding Human Cytomegalovirus
TLDR
The results reveal an unanticipated complexity to the HCMV coding capacity and illustrate the role of regulated changes in transcript start sites in generating this complexity.
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70
TLDR
It is shown that CHIP not only enhances Hsp70 induction during acute stress but also mediates its turnover during the stress recovery process, providing an elegant mechanism for maintaining homeostasis by tuning chaperone levels appropriately to reflect the status of protein folding within the cytoplasm.
Dynamic m6A mRNA methylation directs translational control of heat shock response
TLDR
The elucidation of the dynamic features of 5′UTR methylation and its critical role in cap-independent translation not only expands the breadth of physiological roles of m6A, but also uncovers a previously unappreciated translational control mechanism in heat shock response.
Quantitative profiling of initiating ribosomes in vivo
Cells have evolved exquisite mechanisms to fine-tune the rate of protein synthesis in response to stress. Systemic mapping of start-codon positions and precise measurement of the corresponding
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