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Diabetic heart disease (DHD) is the leading cause of morbidity and mortality among the people with diabetes, with approximately 80% of the deaths in diabetics are due to cardiovascular complications. Importantly, heart disease in the diabetics develop at a much earlier stage, although remaining asymptomatic till the later stage of the disease, thereby(More)
AIM Microangiopathy due to endothelial dysfunction is a major contributing factor to the development of diabetes-induced cardiovascular disease (CVD). Dysregulation of endothelial-specific microRNAs (miRs) is correlated with impaired angiogenesis and cell survival. We investigated the profile of two angiomiRs, miR-126, and miR-132, in the plasma of type 2(More)
Current therapeutic strategies for the treatment of critical limb ischemia (CLI) have only limited success. Recent in vitro evidence in the literature, using cell lines, proposes that the peptide hormone ghrelin may have angiogenic properties. In this study, we aim to investigate if ghrelin could promote postischemic angiogenesis in a mouse model of CLI(More)
Tuberculosis is declared to be an infectious disease of global emergency by WHO. Approximately one-third of the world's population is infected with the tuberculosis. The lengthy and laborious current treatment of 6-9 months is associated with problems like patient noncompliance, multiple drug resistance and persistence of mycobacterium and significant(More)
Aim: Myocardial fibrosis is a well-established cause of increased myocardial stiffness and subsequent diastolic dysfunction in the diabetic heart. The molecular regulators that drive the process of fibrotic events in the diabetic heart are still unknown. We determined the role of the microRNA (miR)-15 family in fibrotic remodelling of the diabetic(More)
Breast Cancer is the leading cause of mortality among the women of age 30 to 60. Endocrine therapy used for the treatment has shown promising results in which the anti-estrogen tamoxifen has been the standard first-line treatment used for more than 30 years. But its side effects like resistance, increase risk of thromboembolism, endometrial cancer and(More)
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