Shruti Malu

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Cytotoxic T-lymphocyte antigen 4 (CTLA4) is a well-studied T cell costimulatory receptor that is known to inhibit T cell activation. In this study, the relationship between strength of the first signal and costimulatory interactions on primary mouse CD4(+) T cells was investigated. CTLA4-CD80/CD86 interactions differentially modulate T cell cycling based on(More)
Interferon-gamma (IFN-gamma) is an important immunomodulatory and pleiotropic cytokine produced, primarily, by activated T lymphocytes and natural killer (NK) cells. We have devised a nitric oxide (NO)-based bioassay for mouse IFN-gamma using resident peritoneal exudate cells (PECs) from C57BL/6 mice. Comparison with three existing bioassays demonstrated(More)
We are developing a new type of antenna-coupled superconducting bolometric detector for millimeterwave and submillimeterwave astrophysics. In this design, a planar antenna couples radiation from free space to the electron system in a small absorber. The absorber is in thermal contact with a small Transition-Edge Sensor (TES), which serves as a thermistor.(More)
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