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AIM To investigate psychopathology in children with neurofibromatosis type 1 (NF1), particularly the prevalence of autism spectrum disorder (ASD) and attention-deficit-hyperactivity disorder (ADHD) symptomatology, using a population-based sampling approach. METHOD Standard questionnaire screen reports were analysed for ASD (Social Responsiveness Scale,(More)
OBJECTIVE To determine the prevalence of autism spectrum disorder (ASD) in Neurofibromatosis Type 1 (NF1). METHODS Second-phase population-based epidemiologic study using an allcase NF1 registry in a defined UK 4.1 million population area. A total of 109 (52.7%) of 207 responders from the initial screening phase were grouped by using the parent-rated(More)
In this paper, a region level based image fusion technique, using wavelet transform, has been implemented and analyzed. The proposed methodology considers regions as the basic feature for representing images and uses region properties for extracting the information from them. A segmentation algorithm is proposed for extracting the regions in an effective(More)
Importance Recent reports have demonstrated a higher incidence of autism spectrum disorder (ASD) and substantially elevated autistic trait burden in individuals with neurofibromatosis type 1 (NF1). However, important discrepancies regarding the distribution of autistic traits, sex predominance, and association between ASD symptoms and attentional problems(More)
Neurofibromatosis Type 1 (NF1) is a common autosomal dominant single-gene disorder, in which the co-occurrence of autism spectrum disorder (ASD) has attracted considerable research interest recently with prevalence estimates of 21-40%. However, detailed characterization of the ASD behavioral phenotype in NF1 is still lacking. This study characterized the(More)
AIMS AND METHODS The aim of this survey was to explore staff attitudes to the indoor smoking ban in a medium secure unit and to ascertain if they had experienced any difficulties in imposing the ban in the four months after its introduction. All staff members available on duty who agreed to participate in the survey were interviewed using a semi-structured(More)
Studies examining the application of information technology to the delivery of health-care services often highlight the anticipated benefits. In consequence, the benefits of health-care information technology adoption, often referred to as 'e-health', are widely reported yet there is limited empirical evidence as to how such benefits can be realized. Design(More)
The large numbers of images has posed increasing challenges to computer systems to store and manage data effectively and efficiently. This paper implements a CBIR system using different feature of images through four different methods, two were based on analysis of color feature and other two were based on analysis of combined color and texture feature(More)
Despite extensive literature, little is known about the mechanisms underlying sex bias in autism spectrum disorder (ASD). This study investigates the sex differences in ASD associated with neurofibromatosis type 1, a single-gene model of syndromic autism. We analysed data from n = 194 children aged 4–16 years with neurofibromatosis type 1. Sex differences(More)
for CRHTT data Jacobs & Barrenho used the same data as Glover et al 2 when they were comparing admissions in primary care trusts with and without crisis resolution and home treatment teams (CRHTTs). However, they employed different methods for their analysis and reached conflicting conclusions. According to Jacobs & Barrenho, the introduction of CRHTTs did(More)