Shripad S. Bhagwat

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Drugs targeting inhibition of kinases for the treatment of inflammation and autoimmune disorders have become a major focus in the pharmaceutical and biotech industry. Multiple kinases from different pathways have been the targets of interest in this endeavor. This review describes some of the recent developments in the search for inhibitors of IKK2, Syk,(More)
In 1975, Hamberg et al. reported evidence for the existence of an unstable platelet-aggregating factor which they named thromboxane A2 (TXA2) and for which they proposed a novel bicyclic oxetane structure (1, below) based on the short half-life of the factor (t1/2 (37 degrees C) = 32 s at pH 7.4) and the isolation of degradation products related to(More)
The concept of preparing a special issue of Purinergic Signalling to highlight progress in the medicinal chemistry of purines arose during the 8th International Symposium on Adenosine and Adenine Nucleotides, which was held in Ferrara, Italy, from 24 May to 28 May 2006. This meeting emphasized the accelerated pace of introduction of new compounds, including(More)
The weight of muscles and bones of the right and left hind limbs has been studied in 60 frogs. In the first ten frogs studied, the number and size of motoneurons of the seventh, eighth and ninth lumbar spinal segments (which give origin to the sciatic nerve) were studied on both sides. This was done to ascertain the relationship between motoneuron size and(More)
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