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Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects
GW572016 is a dual EGFR-ErbB2 inhibitor that has promise as an anticancer agent. Two phase I studies were conducted to determine the safety, tolerability and pharmacokinetics of single and multiple… Expand
High-throughput bioanalytical method using automated sample preparation and liquid chromatography-atmospheric pressure ionspray mass spectrometry for quantitative determination of glybenclamide in…
A liquid chromatographic-mass spectrometric (LC-MS) method with rapid automated sample preparation was developed and validated for determination of glybenclamide in human serum. Glybenclamide and its… Expand
Characterization of the fluorescent dansylamide complex with Chlamydomonas reinhardtii carbonic anhydrase
Abstract The characteristics of the fluorescent complex between carbonic anhydrase from the unicellular green alga, Chlamydomonas reinhardtii, and the fluor
Preparation and evaluation of slurry-packed liquid chromatography microcolumns with inner diameters from 12 to 33 μm
Fused silica capillary liquid chromatography columns with inner diameters between 12 and 33 μm were slurry packed with 5 μm octadecylsilane-modified silica particles. Column efficiencies and van… Expand
Increasing throughput of parallel on-line extraction liquid chromatography/electrospray ionization tandem mass spectrometry system for GLP quantitative bioanalysis in drug development.
- Showchien Hsieh, Tom Tobien, Kevin J. Koch, J. Dunn
- Medicine, Chemistry
- Rapid communications in mass spectrometry : RCM
- 15 February 2004
An approach is described with turbulent flow on-line extraction liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) for GLP quantitative bioanalysis of a drug… Expand