Shoumik Roychoudhury

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Intrinsic resistance toward beta-lactams in methicillin-resistant Staphylococcus aureus strains, a major source of nosocomial infections, is believed to be caused mainly by penicillin-binding protein 2a (PBP2a). This protein resembles other penicillin-binding proteins that are involved in bacterial cell wall biosynthesis and are the targets of active site(More)
We investigated the enzymatic acylation of penicillin-binding protein 2a (PBP 2a) from methicillin-resistant Staphylococcus aureus by beta-lactams. Using a purified, soluble form of the protein (PBP 2a'), we observed beta-lactam-induced in vitro precipitation following first-order kinetics with respect to protein concentration. We used electrospray mass(More)
The American health care system is rife with perverse incentives. Providers are reimbursed for providing more care rather than preventive or higher quality care. Starting in 2012, the Affordable Care Act (ACA) sets Medicare reimbursement rates based on hospital performance for 30day preventable readmissions relative to expectations using 3 specific target(More)
High false alarm rates in intensive care units (ICUs) cause desensitization among care providers, thus risking patients’ lives. Providing early detection of true and false cardiac arrhythmia alarms can alert hospital personnel and avoid alarm fatigue, so that they can act only on true lifethreatening alarms, hence improving efficiency in ICUs. However,(More)
Social media outlets, such as Twitter, provide invaluable information for understanding the social and political climate surrounding particular issues. Millions of people who vary in age, social class, and political beliefs come together in conversation. However, this information poses challenges to making inferences from these tweets. Using the tweets from(More)
BACKGROUND The Hospital Readmissions Reduction Program (HRRP) introduced in October 2012 as part of the Affordable Care Act (ACA), ties hospital reimbursement rates to adjusted 30-day readmissions and mortality performance for a small set of target diagnoses. There is growing concern and emerging evidence that use of a small set of target diagnoses to(More)
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