Shoumik Roychoudhury

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Intrinsic resistance toward beta-lactams in methicillin-resistant Staphylococcus aureus strains, a major source of nosocomial infections, is believed to be caused mainly by penicillin-binding protein 2a (PBP2a). This protein resembles other penicillin-binding proteins that are involved in bacterial cell wall biosynthesis and are the targets of active site(More)
We investigated the enzymatic acylation of penicillin-binding protein 2a (PBP 2a) from methicillin-resistant Staphylococcus aureus by beta-lactams. Using a purified, soluble form of the protein (PBP 2a'), we observed beta-lactam-induced in vitro precipitation following first-order kinetics with respect to protein concentration. We used electrospray mass(More)
Alarm fatigue among care providers inside ICUs due to the high percentages of bedside monitor false alarms, has been identified as one of the top 10 medical hazards. Alarm fatigue results in desensitization among care providers, which ultimately can lead to lower standards of care to patients and also result in fatal consequences. Introduction 2 Goals(More)
The American health care system is rife with perverse incentives. Providers are reimbursed for providing more care rather than preventive or higher quality care. Starting in 2012, the Affordable Care Act (ACA) sets Medicare reimbursement rates based on hospital performance for 30-day preventable readmissions relative to expectations using 3 specific target(More)
BACKGROUND The Hospital Readmissions Reduction Program (HRRP) introduced in October 2012 as part of the Affordable Care Act (ACA), ties hospital reimbursement rates to adjusted 30-day readmissions and mortality performance for a small set of target diagnoses. There is growing concern and emerging evidence that use of a small set of target diagnoses to(More)
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