Shokufeh Sadaghiani

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Recently, a (pro)renin receptor has been identified which mediates profibrotic effects independent of angiotensin II. Because antihypertensive therapy induces renal injury in the clipped kidney of two kidney-1-clip hypertensive rats, we examined the regulation of renin and the (pro)renin receptor in this model. Hypertensive Goldblatt rats were treated with(More)
OBJECTIVE To determine the motor-behavioral and neural correlates of putative functional common variants in the sodium-channel NaV1.8 encoding gene (SCN10A) in vivo in patients with multiple sclerosis (MS). METHODS We recruited 161 patients with relapsing-onset MS and 94 demographically comparable healthy participants. All patients with MS underwent(More)
The present study examined the pathogenesis of interstitial inflammation and fibrosis in antihypertensively treated rats with two-kidney, one-clip hypertension. Hypertensive rats were randomized into four groups: no treatment and moderate, intermediate, and intensified lowering of blood pressure with increasing doses of a vasopeptidase inhibitor for 6 wk.(More)
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF super family that controls many cellular activities including proliferation, migration, differentiation, apoptosis, and inflammation by binding to fibroblast growth factor-inducible 14 (Fn14), a highly inducible cell surface receptor. Recent studies have indicated that(More)
OBJECTIVE Serum urate levels have been associated with risk for and progression of Parkinson's disease (PD). Urate-related compounds are therapeutic candidates in neuroprotective efforts to slow PD progression. A urate-elevating agent is currently under investigation as a potential disease-modifying strategy in people with PD. However, PD is a heterogeneous(More)
  • Peter Bosch, B Eibisch, +108 authors Tamara Djatlova
  • 2004
Dem Institut für Kognitionswissenschaft zugeordnete wissenschaftliche und nicht-wissenschaftliche Mit-glieder: den Neurowissenschaften in einigen Bereichen gut gestützt. In dem Graduiertenprogramm Muster und Regeln wird diese Hypothese untersucht werden.
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