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Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line1
This study shows that influx of Ca2+ and Sr2+ as well as degranulation are dependent on the presence of the canonical transient receptor potential (TRPC) channel protein TRPC5, in addition to STIM1 and Orai1, as demonstrated by knock down of each of these proteins by inhibitory RNAs in a rat mast cell line. Expand
Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome).
A model of SCLS pathogenesis in which nonimmunoglobulin humoral factors such as VEGF and Ang2 contribute to transient endothelial contraction is supported, suggesting a molecular mechanism for this highly lethal disorder. Expand
Amplification of cytokine production through synergistic activation of NFAT and AP‐1 following stimulation of mast cells with antigen and IL‐33
Investigation of the underlying mechanisms revealed that synergy in signaling occurred at the level of TGF‐β‐activated kinase 1, which was then transmitted downstream through JNK, p38 MAP kinase, and AP‐1 as well as co‐operative interactions among transcription factors. Expand
NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation.
NTAL appears to be an important link between the signaling pathways that are initiated by these receptors, culminating in mast cell degranulation, and seems to be differentially regulated by Src kinases and/or Kit kinase, respectively. Expand
Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.
The observations reported herein support the conclusion that NTAL may be differentially utilized by specific receptors for relaying alternative signals and this suggests a flexibility in the function of TRAPs not previously appreciated. Expand
Generation, Isolation, and Maintenance of Rodent Mast Cells and Mast Cell Lines
  • B. M. Jensen, Emily J. Swindle, Shoko Iwaki, Alasdair M. Gilfillan
  • Biology, Medicine
  • Current protocols in immunology
  • 1 August 2006
The protocols used for the isolation and/or culture of mast cell cells are described and the relative merits of their use are discussed. Expand
Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit.
It is demonstrated, for the first time, that Btk is a key regulator of a Kit-mediated amplification pathway that augments Fc epsilonRI-mediated mast cell activation. Expand
Btk Plays a Crucial Role in the Amplification of FcϵRI-mediated Mast Cell Activation by Kit*
It is demonstrated, for the first time, that Btk is a key regulator of a Kit-mediated amplification pathway that augments FcϵRI-mediated mast cell activation. Expand
Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis
Administration of anti-CR3 significantly ameliorated established intestinal inflammation following the intrarectal administration of trinitrobenzene sulfonic acid (TNBS-colitis), as well as colitis and skin inflammation in C57BL/10 RAG-2−/− mice reconstituted with CD4+CD45RBhigh T cells. Expand
Adaptive and innate immune reactions regulating mast cell activation: from receptor-mediated signaling to responses.
Studies that have demonstrated that mast cells can be activated as a consequence of adaptive and innate immune reactions and that these responses can be modified by ligands for other receptors expressed on the surface of mast cells are described. Expand