Shoji Yamamoto

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The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed characteristically on a series of cell adhesion molecules and is synthesized through a key enzyme, glucuronyltransferase (GlcAT-P). We generated mice with a targeted deletion of the GlcAT-P gene. The GlcAT-P -/- mice exhibited normal development(More)
Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenesis, yet their functional relevance is largely unknown. Here, we show that JARID1B, encoding a histone H3 lysine 4 (H3K4) demethylase, is frequently amplified and overexpressed in luminal breast tumors and a somatic mutation in a basal-like breast cancer results in the gain of(More)
Subgraph isomorphism problems have various important applications, while they are generally NP-complete. Though Ullmann's algorithm can be implemented by parallel hardware to accelerate the execution, it requires too many hardware resources. Konishi's algorithm requires much less resources, but it is slower than Ullmann's. Generally, logic gates are(More)
BACKGROUND Vancomycin (VCM) requires dose adjustment based on therapeutic drug monitoring. At Aomori Prefectural Central Hospital, physicians carried out VCM therapeutic drug monitoring based on their experience, because pharmacists did not participate in the dose adjustment. We evaluated the impact of an Antimicrobial Stewardship Program (ASP) on attaining(More)
A portion of this paper was presented at the IS&T/SPIE EI2015 conference held in San Francisco. Abstract In this paper, we propose a method to estimate the reflectance property from refocused images from a light source reflected on an object. The blurred information of the light source on the surface of the object is expected to be a practical method to(More)
An arsenate susceptibility test was performed with transformed and cultured Escherichia coli DH5α cells, which carried recombinant DNA of full-length arsenic (ars) operon, namely a putative membrane permease, ArsP; a transcriptional repressor, ArsR; an arsenate reductase, ArsC; and an arsenical-resistance membrane transporter, Acr3, from the Japanese(More)
We introduce copper molybdenum cyanides of general formula Cu2[Mo(CN)8] · nH2O, which can serve as optofunctional magnetic devices. Their ground states generally stay paramagnetic down to temperatures of the K order but exhibit a spontaneous magnetization upon photoirradiation usually below a few tens of K. To interest us still further, such a ferromagnetic(More)