Shohei Minami

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STUDY DESIGN A prospective trial of preoperative MRI study in patients with "idiopathic" scoliosis. OBJECTIVES To investigate the prevalence of neural axis malformations and the clinical relevance of MRI in the evaluation of patients with idiopathic scoliosis undergoing surgical intervention. SUMMARY OF BACKGROUND DATA With the development of MRI,(More)
BACKGROUND School screening for scoliosis is a powerful tool that can be used to identify children who may have scoliosis. There have been no reports on the recent prevalence of idiopathic scoliosis in Japan since 1988. METHODS A 5-year epidemiologic study was performed to determined the prevalence of idiopathic scoliosis, the curve magnitude, the(More)
STUDY DESIGN The motions of chest wall and diaphragm were measured in patients with scoliosis and healthy individuals using dynamic breathing magnetic resonance imaging. OBJECTIVES To investigate the motions of the chest wall and the diaphragm during deep breathing in patients with idiopathic scoliosis. SUMMARY OF BACKGROUND DATA Despite the central(More)
Adolescent idiopathic scoliosis is a pediatric spinal deformity affecting 2–3% of school-age children worldwide. Genetic factors have been implicated in its etiology. Through a genome-wide association study (GWAS) and replication study involving a total of 1,376 Japanese females with adolescent idiopathic scoliosis and 11,297 female controls, we identified(More)
Adolescent idiopathic scoliosis (AIS) is a common disorder with a strong genetic predisposition. Associations between AIS and common single nucleotide polymorphisms (SNPs) in estrogen receptor genes have been reported. rs9340799 in the gene for estrogen receptor α (ESR1) is reported to be associated with curve severity in Japanese and with AIS(More)
Adolescent idiopathic scoliosis (AIS) is the most common pediatric skeletal disease. We previously reported a locus on chromosome 10q24.31 associated with AIS susceptibility in Japanese using a genome-wide association study (GWAS) consisting of 1,033 cases and 1,473 controls. To identify additional AIS-associated loci, we expanded the study by adding(More)
Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B),(More)
Spinal implants retrieved from 11 patients with scoliosis were examined. All the implants were posterior instrumentation systems made of 316L stainless steel and composed of rods, hooks, and crosslink connectors. Corrosion was classified into grades 0 to 3 based on macroscopic findings of the rod surface at the junction of each hook or crosslink connector.(More)
STUDY DESIGN Analysis of the estrogen receptor gene of girls with idiopathic scoliosis. OBJECTIVES To determine whether estrogen receptor gene polymorphisms correlate with curve severity of adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA Studies suggest that idiopathic scoliosis is a familial condition and that curve progression is related(More)
STUDY DESIGN Familial cases of "idiopathic" scoliosis associated with neurologic abnormalities are reported with a review of the literature. OBJECTIVE To investigate the prevalence of neurologic abnormalities such as syringomyelia, Chiari 1 malformation, and tonsillar ectopia in patients with genetically determined "idiopathic" scoliosis. SUMMARY OF(More)