Shohei Kumagai

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Activation of cardiac STAT3 by IL-6 cytokine family contributes to cardioprotection. Previously, we demonstrated that IL-11, an IL-6 cytokine family, has the therapeutic potential to prevent adverse cardiac remodeling after myocardial infarction; however, it remains to be elucidated whether IL-11 exhibits postconditioning effects. To address the possibility(More)
AIMS Leucine-rich α2-glycoprotein (LRG) is considered as a biomarker of the clinical activities of chronic inflammatory diseases, including heart failure. However, its pathophysiological roles in cardiac remodelling after myocardial infarction (MI) remain to be clarified. In this study, we have addressed functional roles of LRG in cardiac remodelling after(More)
Activation of CaMKII induces a myriad of biological processes and plays dominant roles in cardiac hypertrophy. Caveolar microdomain contains many calcium/calmodulin-dependent kinase II (CaMKII) targets, including L-type Ca2+ channel (LTCC) complex, and serves as a signaling platform. The location of CaMKII activation is thought to be critical; however, the(More)
Hydrostatic (physical) pressure effects on the electrical resistivity of a bromido-bridged palladium compound, [Pd(en)2Br](Suc-C5)2·H2O, were studied. The charge-density-wave to Mott-Hubbard phase transition temperature (TPT) steadily increased with pressure. By a comparison of the effects of the chemical and physical pressures on TPT, it was estimated that(More)
The optical gap in a series of bromo-bridged platinum chain complexes, [Pt(en)2Br](C(n)-Y)2·H2O (en = ethylenediamine; C(n)-Y = dialkyl sulfosuccinate; n = the number of carbon atoms), was controlled by using chemical pressure. From the single-crystal structure, [Pt(en)2Br](C6-Y)2·H2O is in a mixed-valence state at 200 K. In addition, Pt-Pt distances(More)
We synthesized a series of one-dimensional (1D) iodo-bridged platinum compounds with long alkyl chains on the counterions. In the compounds, the shortest Pt···Pt distance and the smallest band gap thus far reported were achieved. These compounds were found to be in a CDW state by using synchrotron X-ray diffraction measurements.
Fibrosis is one of the most common pathological alterations in heart failure, and fibroblast migration is an essential process in the development of cardiac fibrosis. Experimental autoimmune myocarditis (EAM) is a model of inflammatory heart disease characterized by inflammatory cell infiltration followed by healing without residual fibrosis. However, the(More)
Polymorphism in formate-based dense metal-organic frameworks with the general formula ABX3 is predicted by quantum chemical calculations and confirmed experimentally. In particular [NH3NH2]Zn(HCOO)3 crystallizes in two different polymorphs, a perovskite-like framework and a chiral structure with hexagonal channels. A detailed thermodynamic analysis reveals(More)
Quasi-one-dimensional halogen-bridged Pt, Pd, and Ni complexes (MX chains) are a family of materials with potential charge bistability: M(II)-M(IV) mixed valence charge-density-wave (CDW) and M(III) averaged valence Mott-Hubbard (MH) states can form. However, until recently, no examples of MX chains showing charge bistability have been reported.(More)
We synthesized and characterized bromide-bridged Pd(III) chain complexes, [Pd(en)2Br](MalCn-Y)2·H2O (en = ethylenediamine; MalCn-Y = dialkyl sulfomalonate; n: the number of carbon atoms) (n = 7 and 12). The compound with n = 7 showed charge-bistability near room temperature. In addition, it is shown that the Pd(III) state is maintained in the thin film(More)
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