Sho-ichi Takayanagi

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The biaryl moiety is ubiquitous in natural products, pharmaceuticals, polymers, sensors, and in ligands for transition-metal catalysts. A number of useful methods for the preparation of these compounds have been developed based on the transition-metal-catalyzed cross-coupling of aryl halides with aryl metal species through Stille, Suzuki, Negishi, and(More)
For the synthesis of a 12-membered salicylic macrolide scaffold, ring-closing metathesis (RCM) of a omega-diene compound was planned. The stereochemical outcome of the RCM reaction changed depending on the type of Ru catalyst that was used; a "first-generation" Grubbs catalyst produced exclusively the E isomer and "second-generation" catalysts provided a(More)
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