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PKA/AKAP/VR-1 Module: A Common Link of Gs-Mediated Signaling to Thermal Hyperalgesia
The PKA/AKAP/VR-1 module presents as the molecular correlate of Gs-mediated inflammatory hyperalgesia, and potentiation of current responses to heat depends on phosphorylation at predicted PKA consensus sites.
Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins.
State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na+ Channel Isoforms by Ranolazine
Both muscle and neuronal Na+ channels are as sensitive to ranolazine block as their cardiac counterparts and at its therapeutic plasma concentrations, ranolazines interacts predominantly with the open but not resting or inactivated Na+ channel channels.
Block of Human Heart hH1 Sodium Channels by the Enantiomers of Bupivacaine
Differences in bupivacaine stereoselectivity and intrinsic affinity between hH1 and &mgr;1 Na+ channels are small and most likely of minor clinical relevance.
Block of Neuronal Na+ Channels by Antidepressant Duloxetine in a State-dependent Manner
Duloxetine blocks persistent late Nav1.7 Na+ currents preferentially, which may in part account for its analgesic action.
Single point mutations affect fatty acid block of human myocardial sodium channel α subunit Na+ channels
- Yong-Fu Xiao, Q. Ke, Alexander Leaf
- Biology, MedicineProceedings of the National Academy of Sciences…
- 6 March 2001
Results demonstrate that substitution of asparagine with lysine at the site of 406 in the domain-1-segment-6 region (D1-S6) significantly decreased the inhibitory effect of PUFAs on INa, and coexpression with β1 decreased this effect even more.
Sequencing and Amplified Restriction Fragment Length Polymorphism Analysis of Ribonucleotide Reductase Large Subunit Gene of the White Spot Syndrome Virus in Blue Crab (Callinectes sapidus) from…
WSSV rr1-specific RsaI amplified restriction fragment length polymorphism of an amplified 1156-bp fragment thus distinguished the New Jersey blue crab samples from the other WSSV isolates.
State-dependent block of voltage-gated Na+ channels by amitriptyline via the local anesthetic receptor and its implication for neuropathic pain
Tryptophan scanning of D1S6 and D4S6 C-termini in voltage-gated sodium channels.
State-dependent Block of Wild-type and Inactivation-deficient Na+ Channels by Flecainide
It is concluded that flecainide directly blocks persistent late Na+ currents with a high affinity and the fast-inactivation gate, probably via its S6 docking site, may further stabilize the flec Cainide-receptor complex in wild-type Na+ channels.