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Endothelial immunogenicity--a matter of matrix microarchitecture.
TLDR
Results indicate that the immediate environment of EC might play a pivotal role in initiating and regulating of different vascular diseases, and cell-matrix interconnections appear to govern endothelial immunogenicity and interactions between EC and immune cells.
Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability.
TLDR
Based on several tests, it is concluded that the absorption mechanism of all tested analogs is paracellular, regardless of the structural or conformational modifications.
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity.
TLDR
Backbone cyclization was shown to produce a potential drug lead for treating obesity and one analog, peptide 1 (BL3020-1), was selected according to its selectivity in activating the MC4R, its favorable transcellular penetration through enterocytes and its enhanced intestinal metabolic stability.
Endothelial cell‐matrix interactions determine maturation of dendritic cells
TLDR
It is demonstrated for the first time that interactions of EC with an underlying 3D matrix affect the ability of EC to drive DC maturation.
Implications on Emergence of Antimicrobial Resistance as a Critical Aspect in the Design of Oral Sustained Release Delivery Systems of Antimicrobials
TLDR
The need to consider the emergence of antimicrobial resistance as a goal equally important to microbiological and clinical cure, when designing oral sustained-release delivery systems of antimicrobials is illustrated.
NF-κB Activity in Endothelial Cells is Modulated by Cell Substratum Interactions and Influences Chemokine-Mediated Adhesion of Natural Killer Cells
Because changes in subendothelial matrix composition are associated with alterations of the endothelial immune phenotype, we sought to understand if cytokine-induced NF-κB activity and downstream
Treatment of combined traumatic brain injury and hemorrhagic shock with fractionated blood products versus fresh whole blood in a rat model
TLDR
It is suggested that resuscitation with FWB is a feasible modality in the combined TBI + hypovolemic shock scenario, and may result in improved outcomes compared to platelet-free component blood products.
Severe Traumatic Brain Injury and Controlled Hemorrhage in Rats: Quest for the Optimal Mean Arterial Blood Pressure After Whole Fresh Donor Blood Resuscitation
TLDR
It is found that mild resuscitation with goals of restoring MAP to 80 mmHg (which is lower than baseline) provided best results when considering hemodynamic stability, survival, and neurological outcomes.
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