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The effects of phenolcarboxylic acids, caffeic acid, p-coumaric acid, and ferulic acid on the generation of superoxide anion and the production of lipid peroxide induced by superoxide anion were studied. Only ferulic acid anion among the phenolcarboxylic acids scavenged superoxide. Caffeic acid and ferulic acid inhibited lipid peroxidation induced by(More)
The leaves of Artemisia princeps PAMP have traditionally been used as teas and foods in Japan. Polyphenols in Artemisia plants have been shown to have inhibitory effects against biological damages. The inhibitory effects of polyphenols in the leaves of A. princeps PAMP were investigated on protein fragmentation induced by Cu(II)-H(2)O(2) in vitro. The total(More)
The herbal medicine "Saiboku-to" (ST) has been used for the treatment of bronchial asthma. ST was found to inhibit histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80. Its inhibitory effects were concentration-related and somewhat weaker than disodium cromoglycate, a known inhibitor of histamine release and(More)
Possible inhibitory effects were investigated for four isoflavones, biochanin A, daidzein, formononetin and genistein on lipid peroxidation by reactive oxygen species. Biochanin A, formononetin and genistein inhibited lecithin peroxidation which was induced by hydroxy radical generation, by interaction of haemoglobin and hydrogen peroxide. Daidzein and(More)
Effects of Astragali Radix, the root of Astragalus membrauaceus Bunge, were investigated on oxidative stress such as lipid peroxidation and protein oxidative modification by copper. The results showed that these effects are similar to those of mannitol and superoxide dismutase as a free radical scavenger. It was demonstrated that Astragali Radix have(More)
In the present study the authors report on the enhancing effect of aluminum(III) (Al[III]) on iron(II)(Fe[II])-induced lipid peroxidation (LPO) of mice brain homogenate, which occurs in a concentration and time-dependent manner. No evidence of LPO caused by Al alone was found. Both Al(III) and Fe(II) ions induced protein oxidative modifications in mice(More)
We present the results of an in vitro investigation of the inhibitory effects of sophoraflavanones B and H isolated from Sophora mooracroftiana Beth ex Baker on copper-induced protein oxidative modification. They inhibited copper-induced protein oxidative modification. Their effects were stronger than those of naringenin as a related flavanone, and of(More)
Daidzein and its glycoside daidzin are isoflavones. Their antioxidative effects were compared in vitro. Although both compounds inhibited protein oxidative modification by copper, the inhibitory effect of daidzein was stronger than that of daidzin. Because daidzein showed a greater affinity for Cu2+, the antioxidant effect of these isoflavones may be(More)