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High‐fat and high‐cholesterol diet rapidly induces non‐alcoholic steatohepatitis with advanced fibrosis in Sprague–Dawley rats
TLDR
This work established a dietary model of NASH with rapid progression to fibrosis using genetically normal rats to establish a guide for the development of fibrosis in patients with non‐alcoholic steatohepatitis. Expand
D-psicose, an epimer of D-fructose, favorably alters lipid metabolism in Sprague-Dawley rats.
TLDR
It is indicated that the D-psicose diet decreases lipogenesis, increases fatty acid oxidation, and enhances 24 h energy expenditure, leading to d-PSicose's potential for weight management. Expand
Theflavins and theasinensin A derived from fermented tea have antihyperglycemic and hypotriacylglycerolemic effects in KK-A(y) mice and Sprague-Dawley rats.
TLDR
Results indicate TFs and TSA induce antihyperglycemic responses in diabetic mice and are hypotriacylglycerolemic in rats by suppressing intestinal fat absorption. Expand
Olive leaf extract prevents spontaneous occurrence of non‐alcoholic steatohepatitis in SHR/NDmcr‐cp rats
TLDR
The data suggest that olive leaf extract may help prevent NASH, presumably through its anti‐oxidative activity. Expand
Polyphenol composition of a functional fermented tea obtained by tea-rolling processing of green tea and loquat leaves.
TLDR
Isolation of these new and known compounds confirms that reactions previously demonstrated by in vitro model experiments actually occur when fresh tea leaves are mechanically distorted and bruised during the production process. Expand
Anti-Obesity and Hypotriglyceridemic Properties of Coffee Bean Extract in SD Rats
TLDR
The results suggest that CBE has potent anti-obesity and hypotriglyceridemic properties, and there is a possibility that these effects are exerted at least in part by the suppression of lipogenesis and the acceleration of lipolysis. Expand
A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis.
TLDR
Histopathological analysis revealed that the HFC diets induced liver cirrhosis in conjunction with hepatic features of NASH in Sprague-Dawley rats within 18 weeks, and altered gene expression and enzyme activity to accumulate lipid and bile acid in the liver. Expand
Transepithelial transport of theasinensins through Caco-2 cell monolayers and their absorption in Sprague-Dawley rats after oral administration.
TLDR
The dimers of condensed catechins, theasinensins B and A, can be absorbed intact into rat blood and transported across Caco-2 cell monolayers probably through a TJ paracellular pathway. Expand
Hypoglycemic Activity of Eriobotrya japonica Seeds in Type 2 Diabetic Rats and Mice
TLDR
Eriobotrya japonica seeds had a hypoglycemic property and the effect is attributable to the components extracted by ethanol, these actions being mainly exerted by the ethanol extract of the seeds. Expand
Increase of theaflavin gallates and thearubigins by acceleration of catechin oxidation in a new fermented tea product obtained by the tea-rolling processing of loquat ( Eriobotrya japonica ) and
TLDR
The results from in vitro experiments suggested that acceleration of catechin oxidation was caused by the strong oxidation activity of Loquat leaf enzymes and a coupled oxidation mechanism with caffeoyl quinic acids, which are the major phenolic constituents of loquat leaves. Expand
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