Shizuka Katsuki

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Nitric oxide gas (NO) increased guanylate cyclase [GTP pyrophosphate-lyase (cyclizing), EC] activity in soluble and particulate preparations from various tissues. The effect was dose-dependent and was observed with all tissue preparations examined. The extent of activation was variable among different tissue preparations and was greatest (19- to(More)
BACKGROUND Aberrant crypt foci of the colon are possible precursors of adenoma and cancer, but these lesions have been studied mainly in surgical specimens from patients who already had colon cancer. METHODS Using magnifying endoscopy, we studied the prevalence, number, size, and dysplastic features of aberrant crypt foci and their distribution according(More)
BACKGROUND In recent years, there has been an increasing number of cases of early gastric cancer (T1, NX) with intramucosal invasion, which are untreatable by surgical or endoscopic mucosal resection (EMR) because of their high risk. Currently, no adequate treatment is available for such patients. AIM The main objective of this study was to evaluate(More)
Histological examinations of the intracerebral and retinal arteries were preformed in patients who had cerebrovascular disease and in those cases who did nott. Fibrinoid degeneration, fibrous nodule, and splitting, which are most frequently found in putamen, thalamus and pons, are thought to be the main changes in cerebral hemorrhage and infarction. Fibrous(More)
Sodium nitroprusside, nitroglycerin, sodium azide and hydroxylamine increased guanylate cyclase activity in particulate and/or soluble preparations from various tissues. While sodium nitroprusside increased guanylate cyclase activity in most of the preparations examined, the effects of sodium azide, hydroxylamine and nitroglycerin were tissue specific.(More)
Anthopleurin-A (AP-A), a polypeptide with MW ca. 5500 (53 amino acids), isolated from the sea anemone, Anthopleura xanthogrammica (Brandt), elicited a potent positive inotropic effect but without an accompanying chronotropic effect on the isolated cardiac muscles of rat, rabbit, guinea pig and cat. Similarly in dogs and cats in situ, i.p. injections of AP-A(More)
Function of the inferior longitudinal fasciculus (ILF), which connects the anterior temporal and occipital lobes, has not been clearly demonstrated in the human brain. A 47-year-old woman with visual memory disturbance as demonstrated by the Wechsler Memory Scale-Revised presented with possible brain tumor in the right temporal lobe. Diffusion tensor(More)
The Long-Evans Cinnamon (LEC) rat is a mutant strain established from Long-Evans rats that displays spontaneous hepatitis and liver cancer. We previously demonstrated that LEC rats died of acute ethanol intoxication after being fed a liquid diet containing 5% ethanol. Furthermore, we found that both alcohol dehydrogenase (ADH) and aldehyde dehydrogenase(More)
The acid deoxyribonucleases in homogenates of human gastric mucosa and cervix uteri were purified extensively by a procedure including DEAE-cellulose and phosphocellulose chromatographies, gel filtration, and isoelectric focusing. The enzymes in the two preparations had similar properties. The active protein was resolved into at least two forms with(More)