Learn More
— This paper is concerned with the problem of robust control for a class of uncertain stochastic systems with discrete and distributed time-varying delays via dynamic output feedback control. The parameter uncertainties of system matrices are assumed to be norm-bounded. The purpose is to design a dynamic output feedback controller such that the closed-loop(More)
BACKGROUND Microglial activation plays an important role in neurodegenerative diseases through production of nitric oxide (NO) and several pro-inflammatory cytokines. Lipoxins (LXs) and aspirin-triggered LXs (ATLs) are considered to act as 'braking signals' in inflammation. In the present study, we investigated the effect of aspirin-triggered LXA4 (ATL) on(More)
Inflammation, which is known to be detrimental to the neurological outcome during the acute phase after ischemia, provides a potential preventative or therapeutic approach for acute stroke. Lipoxins are endogenous lipoxygenase derived eicosanoids and evokes protective actions in a range of pathophysiologic processes. Here, we evaluated the efficacy of 5(More)
LXA4 methyl ester (LXA4ME), a lipoxin A4 analog, reduces ischemic insult in the rat models of transient or permanent cerebral ischemic injury. We investigated whether LXA4ME could ameliorate blood–brain barrier (BBB) dysfunction after stroke by reducing matrix metalloproteinase (MMP)-9 expression. Adult male rats were subjected to 2-h middle cerebral artery(More)
Microglia play key roles in innate immunity, homeostasis, and neurotropic support in the central nervous system. Similar to macrophages, microglia adopt two different activation phenotypes, the classical and alternative activation. Resolvin D1 (RvD1) is considered to display potent anti-inflammatory and pro-resolving actions in inflammatory models. In this(More)
Neuroprotective effect of lipoxin A(4) methyl ester (LXA(4) ME) was tested in a rat model of permanent middle cerebral artery occlusion. LXA(4) ME was administrated through intracerebroventricular injection immediately after middle cerebral artery was occluded. Administration of LXA(4) ME ameliorated neurological deficit, reduced infarct volume, attenuated(More)
— This paper deals with the consensus control of a multi-agent system with state and measurement disturbances, and proposes a distributed dynamic output feedback protocol. By defining an appropriate controlled output, the consensus control problem is reformulated as an H ∞ control problem. Using H ∞ techniques, a sufficient condition in terms of linear(More)
INTRODUCTION Fungal infection is increasingly common in critical illness with severe sepsis, but the influence of invasive fungal infection (IFI) on severe sepsis is not well understood. The aim of this study was to investigate the impact that IFI has on the outcomes of critically ill surgical patients with severe sepsis in China by means of matched cohort(More)
— This paper considers the flocking of a class of multi-agent systems with switching topology in a noisy environment. We have shown that although the information is contaminated by variable noises, all agents can form and maintain flocking if the gradient of the environment is bounded and the interaction graphs are jointly connected. The proposed results(More)