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Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
- D. Li, Q. Wang, +20 authors W. Chen
- Medicine, Biology
- Toxicological sciences : an official journal of…
- 1 February 2012
Identification of aberrant microRNA (miRNA) expression during chemical carcinogen-induced cell transformation will lead to a better understanding of the substantial role of miRNAs in cancer… Expand
LncRNA CASC9 promotes esophageal squamous cell carcinoma metastasis through upregulating LAMC2 expression by interacting with the CREB-binding protein
Esophageal squamous cell carcinoma (ESCC) is the main subtype of esophageal cancer. Long noncoding RNAs (lncRNAs) are thought to play a critical role in cancer development. Recently, lncRNA CASC9 was… Expand
CpG Site–Specific Hypermethylation of p16INK4α in Peripheral Blood Lymphocytes of PAH-Exposed Workers
- P. Yang, Junxiang Ma, +20 authors W. Chen
- Cancer Epidemiology, Biomarkers & Prevention
- 25 October 2011
Background: Sufficient epidemiologic evidence shows an etiologic link between polycyclic aromatic hydrocarbons (PAH) exposure and lung cancer risk. While the genetic modifications have been found in… Expand
Rho Guanine Nucleotide Exchange Factor 5 Increases Lung Cancer Cell Tumorigenesis via MMP-2 and Cyclin D1 Upregulation
We sought to elucidate the role of Rho guanine nucleotide exchange factor 5 (ARHGEF5) in tumorigenesis of lung adenocarcinoma cells. ARHGEF5 protein levels were assessed in 91 human lung… Expand
A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma
Esophageal cancer is one of the leading causes of cancer-related mortality because of poor prognosis. Long noncoding RNAs (lncRNAs) have been gradually demonstrated to play critical roles in cancer… Expand
miRNA 146a promotes chemotherapy resistance in lung cancer cells by targeting DNA damage inducible transcript 3 (CHOP).
The underlying molecular mechanism of lung cancer drug resistance is poorly understood. The mediator of endoplasmic reticulum stress CHOP (DNA damage inducible transcript 3) promotes stress-induced… Expand
Upregulation of a novel lncRNA LINC01980 promotes tumor growth of esophageal squamous cell carcinoma.
- Shixin Zhang, Y. Liang, +7 authors Y. Bai
- Biology, Medicine
- Biochemical and biophysical research…
- 21 May 2019
An increasing number of long noncoding RNAs (lncRNAs) have been discovered, and dysregulation of lncRNAs plays critical roles in tumorigenesis and tumor progression. In this study, we identified a… Expand
Suppression of cell proliferation and collagen production in cultured human hypertrophic scar fibroblasts by Sp1 decoy oligodeoxynucleotide.
- Chenliang Deng, Jianghong Zheng, +4 authors S. Yang
- Biology, Medicine
- Molecular medicine reports
- 1 March 2013
Hypertrophic scars are characterized by the abnormal proliferation of fibroblasts and an overproduction of collagen. The Sp1 transcription factor is involved in the… Expand
Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression
Multidrug resistance (MDR) often leads to chemotherapy failure of lung cancer and has been linking to the cellular expression of several DNA transcription‐ and repair‐related genes such as Trps1 and… Expand