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Ischemic postconditioning (PostC) and perconditioning (PerC) provide practical methods for protecting the heart against ischemia-reperfusion (I/R) injury, but their combined effects have not been studied in detail. Using an in vivo rat I/R model, we tested 1) whether additive effects were produced when local PostC was preceded by varying doses of remote(More)
BACKGROUND Microvascular reflow is crucial for myocyte survival during ischaemia/reperfusion injury. AIMS We aimed to assess if salvianolate, a highly purified aqueous extract from Radix salviae miltiorrhizae, could improve impaired microvascular reflow induced by ischaemia/reperfusion injury, using a porcine closed-chest model. METHODS Left anterior(More)
Fungal infection stimulates the canonical C-type lectin receptor (CLR) signaling pathway via activation of the tyrosine kinase Syk. Here we identify a crucial role for the tyrosine phosphatase SHP-2 in mediating CLR-induced activation of Syk. Ablation of the gene encoding SHP-2 (Ptpn11; called 'Shp-2' here) in dendritic cells (DCs) and macrophages impaired(More)
ADP plays an important part in platelet aggregation by activating P2Y1 and P2Y12 receptors. The ADP antagonist MRS2179 has been used in thrombosis-related treatments but its effects on vein graft (VG) remodeling is undefined. We examined the effect of MRS2179 on VG intimal hyperplasia and explored the mechanism of action. A mouse model of VG transplantation(More)
The limitation of exiting instruction-words software birthmark was high complexity, this paper introduced the idea of characteristics selection in text classification into the field of software birthmark, and proposed an instruction-words software birthmark selection method based on CHI (&#x03C7;<sup>2</sup> statistics). The birthmark selection algorithm(More)
Zihou Deng1, Shixin Ma1, Hao Zhou2, Aiping Zang1, Yiyuan Fang1, Tiantian Li1, Huanjing Shi1, Mei Liu1, Min Du1, Patricia R. Taylor3, Helen H. Zhu4, Jiangye Chen5, Guangxun Meng1, Fubin Li6, Changbin Chen1, Yan Zhang1, Xin-Ming Jia7, Xin Lin8, Xiaoming Zhang1, Eric Pearlman3, Xiaoxia Li2, Gen-Sheng Feng9, and Hui Xiao1,*,¶ 1Key Laboratory of Molecular(More)
INTRODUCTION: The mortality due to cardiogenic shock complicating acute myocardial infarction (AMI) is high even in patients with early revascularization. Infusion of low dose recombinant human brain natriuretic peptide (rhBNP) at the time of AMI is well tolerated and could improve cardiac function. OBJECTIVE: The objective of this study was to evaluate(More)
OBJECTIVES This study's aim was to evaluate the protective effects of salvianolate on contrast-induced nephropathy after primary percutaneous coronary intervention (PPCI) compared with normal saline (NS) hydration. METHODS We enrolled patients with acute myocardial infarction who underwent PPCI in 3 centers in Shanghai. The patients were randomly assigned(More)
TLR7/9 signals are capable of mounting massive interferon (IFN) response in plasmacytoid dendritic cells (pDCs) immediately after viral infection, yet the involvement of epigenetic regulation in this process has not been documented. Here, we report that zinc finger CXXC family epigenetic regulator CXXC5 is highly expressed in pDCs, where it plays a crucial(More)
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