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A C825T polymorphism of the gene encoding the G protein β3 subunit (GNB3) is associated with enhanced G protein activity and increased intracellular signal transduction. The 825T allele has been implicated in the development of hypertension in some ethnic groups, especially in whites. Studies in Asians and blacks are more controversial, and little(More)
BACKGROUND Drinking alcohol has a long tradition in Chinese culture. However, data on the prevalence and patterns of alcohol consumption in China, and its main correlates, are limited. METHODS During 2004-08 the China Kadoorie Biobank recruited 512,891 men and women aged 30-79 years from 10 urban and rural areas of China. Detailed information on alcohol(More)
BACKGROUND Few large studies in China have investigated total physical activity and sedentary leisure time and their associations with adiposity. OBJECTIVE We investigated determinants of physical activity and sedentary leisure time and their associations with adiposity in China. DESIGN A total of 466,605 generally healthy participants (age: 30-79 y,(More)
Incidence of esophageal adenocarcinoma (EAC) has increased sharply in Western Europe and United States over the past three decades. Nearly all cases of EAC in the west are thought to be associated with Barrett's esophagus (BE) at the time of diagnosis. Regions in the Henan province of China have one of world's highest incidences of esophageal cancer, yet(More)
INTRODUCTION Blood pressure is a major cause of cardiovascular disease (CVD) and both may increase as outdoor temperatures fall. However, there are still limited data about seasonal variation in blood pressure and CVD mortality among patients with prior-CVD. METHODS We analysed data on 23 000 individuals with prior-CVD who were recruited from 10 diverse(More)
BACKGROUND Despite the great burden of chronic respiratory diseases in China, few large multicentre, spirometry-based studies have examined its prevalence, rate of underdiagnosis regionally or the relevance of socioeconomic and lifestyle factors. METHODS We analysed data from 512 891 adults in the China Kadoorie Biobank, recruited from 10 diverse regions(More)
BACKGROUND Increasing evidence has suggested that major depression (MD) is associated with an increased risk of ischemic heart disease (IHD). We examined this association in Chinese adults using data from the China Kadoorie Biobank study. METHODS AND RESULTS Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004-2008)(More)
Importance In China, diabetes prevalence has increased substantially in recent decades, but there are no reliable estimates of the excess mortality currently associated with diabetes. Objectives To assess the proportional excess mortality associated with diabetes and estimate the diabetes-related absolute excess mortality in rural and urban areas of(More)
BACKGROUND Previous studies of mostly Western women have reported inconsistent findings on the association between age at menarche and risk of cardiovascular disease (CVD). Little is known about the association in China where there has been a large intergenerational decrease in women's mean age at menarche. METHODS The China Kadoorie Biobank recruited(More)
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