Shivkumar Madagi

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Lyme disease is an infectious disease caused by a spirochete Borrelia burgdorferi ZS7. This spirochete is most often spread by ticks. Single antibiotic therapy is sufficient for containment of the early stage progression of the disease but combinational therapy is more preferred in later stages. Research is in progress for the development of drugs against(More)
Increase in biological data at an alarming rate, has made possible the use of such data in identification of drug targets. Ureaplasma urealyticum serovar 10 str. ATCC 33699 is a causative agent for sexually transmitted infections. In present study novel comparative genomic approach is used to identify the drug targets. This approach has been successfully(More)
In silico differential genomics helps to identify genes that encode for unique metabolism with relation to human. The genomic database provides a vast amount of useful information for the drug target identification. The subtractive dataset obtained comparatively between the human and the pathogen genome, differentially provides information about the genes(More)
OBJECTIVE Sexually transmitted diseases (STD) are the serious public health problems and also impose a financial burden on the economy. Sexually transmitted infections are cured with single or multiple antibiotics. However, in many cases the organism showed persistence even after treatment. In the current study, the set of druggable targets in STD pathogens(More)
In silico subtractive/differential genome analysis is a powerful approach for identifying genus or species-specific genes, or groups of genes that are responsible for a unique phenotype. Subtractive genomic approach is one of the most useful strategies helpful in identification of potential drug targets. Availability of genome sequences of pathogens has(More)
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