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  • Leon M. Tai, Shivesh Ghura, +11 authors Mary Jo LaDu
  • Biology, Medicine
  • Journal of neurochemistry
  • 2015 (First Publication: 18 March 2015)
  • Abstract Chronic glial activation and neuroinflammation induced by the amyloid‐β peptide (Aβ) contribute to Alzheimer's disease (AD) pathology. APOE4 is the greatest AD‐genetic risk factor;Continue Reading
  • Tao Teng, Li Dong, +5 authors James C Lee
  • Medicine, Biology
  • Molecular Neurobiology
  • 2018 (First Publication: 1 May 2019)
  • Cytosolic phospholipase A2 (cPLA2) mediates oligomeric amyloid-β peptide (oAβ)-induced oxidative and inflammatory responses in glial cells. Increased activity of cPLA2 has been implicated in theContinue Reading
  • Shivesh Ghura, Leon M. Tai, +4 authors Mary Jo LaDu
  • Medicine, Biology
  • Scientific reports
  • 2016 (First Publication: 7 July 2016)
  • Although the cause of Alzheimer’s disease (AD) is unknown, glial-induced neuroinflammation is an early symptom. Familial AD is caused by increases in amyloid-beta (Aβ) peptide, particularly solubleContinue Reading