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In this paper, we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and a peri-synaptic astrocyte controlling Ca(2 + ) dynamics inside the synaptic bouton. This in turn(More)
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP). Recently, Perea and Araque (Science 317:1083–1086, 2007) demonstrated a role of astrocytes in induction of(More)
The hippocampus is central to our understanding of memory formation and retrieval. Its CA1 region is known for encoding contextual memory. Here, using a computational approach, which embeds existing physiological data, we propose a particular role of astrocytes in contextual memory retrieval. We provide a quantitative framework under which the astrocyte(More)
Huxley revolutionized the field of neu-roscience when they provided a quantitative description of the squid axon action potential generation and propagation (Hodgkin and Huxley, 1952). The seminal article described how to recreate a biological phenomenon inside a computer using a mathematical model. Ever since, this quantitative approach has helped us in(More)
Research in neuroscience has come a long way since it was first hypothesized, in the early twentieth century, that dynamic changes in ion permeability underlie an event termed as action potential (Bernstein, 1912). Research along the same lines in the 1950s by Hodgkin and Huxley (1952) elucidated the dependence of action potential on the permeability of(More)
Ever since memory deficits were characterized in patient H.M. (Scoville and Milner, 1957), it has become clear that the hippocampal region is an important player in memory acquisition and retrieval. Not to mention that memory is of paramount importance for maintaining relationships, achieving personal and professional goals, and carrying out even simple(More)
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