Shivendra Tewari

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Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP). Recently, Perea and Araque (Science 317:1083–1086, 2007) demonstrated a role of astrocytes in induction of(More)
The hippocampus is central to our understanding of memory formation and retrieval. Its CA1 region is known for encoding contextual memory. Here, using a computational approach, which embeds existing physiological data, we propose a particular role of astrocytes in contextual memory retrieval. We provide a quantitative framework under which the astrocyte(More)
Huxley revolutionized the field of neu-roscience when they provided a quantitative description of the squid axon action potential generation and propagation (Hodgkin and Huxley, 1952). The seminal article described how to recreate a biological phenomenon inside a computer using a mathematical model. Ever since, this quantitative approach has helped us in(More)
—Calcium is a vital second messenger used in signal transduction. Calcium controls secretion, cell movement, muscular contraction, cell differentiation, ciliary beating and so on. Two theories have been used to simplify the system of reaction-diffusion equations of calcium into a single equation. One is excess buffer approximation (EBA) which assumes that(More)
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