Shivani Badal

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Cytochrome P450 (CYP) enzyme inhibitory properties of six chromenylated amide compounds (CAs) from Amyris plumieri are described. Inhibition of CYP microsomes (CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4 and CYP2C19) was monitored using a fluorescent assay. Potent inhibition was found against CYP1A1 with IC(50) and K(i) for CA1 (acetamide), being the lowest at(More)
As one of the main extra-hepatic cytochrome P450 (CYP) enzymes, CYP1A1 has been comprehensively investigated for its ability to metabolize both exogenous and endogenous compounds into their carcinogenic derivatives. These derivatives are linked to cancer initiation and progression. The compound benzo-a-pyrene (BaP), a copious and noxious compound present in(More)
Giant parovarian cysts are rarely seen in adolescents. The cysts predominantly arise from mesothelium covering the peritoneum, usually in the broad ligament but sometimes may be seen between ovaries and ipsilateral fallopian tubes. Parovarian cysts constitute 10 to 33% of adnexal masses and are usually seen in the 3rd and 4th decades of life. These cysts(More)
The organized, tightly regulated signaling relays engaged by the cannabinoid receptors (CBs) and their ligands, G proteins and other effectors, together constitute the endocannabinoid system (ECS). This system governs many biological functions including cell proliferation, regulation of ion transport and neuronal messaging. This review will firstly examine(More)
Interventional radiology (IR) came a long way in the path of development of minimally invasive therapies. Need for anesthesia and sedation for some of these procedures have increased as it cause significant discomfort to the patient and requires patient immobility. As recommended by The Royal College of Radiologists and the Joint Commission for(More)
Opioid receptors (ORs), μOR, δOR, κOR and ORL1 mediate numerous signaling cascades, most importantly, through the modulation of ion channels. Research demonstrates the role of OR mediated signal transduction in treating pain, cancer, neurodegenerative disorders and cardiac insults. Yet, the primary application of drugs that modulate ORs is analgesia.(More)
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